cns-2019-scientifictracks

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June 10-11, 2019 | Edinburgh, Scotland

Central Nervous System and Therapeutics

International Conference on

Journal of Neurology and Neurorehabilitation Research | Volume 4

allied

academies

Anti-NMDA receptor antibodies and CNS Lupus

Czeslawa Kowal

The Feinstein Institute for Medical Research, USA

ognitive impairment, one of the most prevalent (40-90%)

andmost debilitating symptoms in neuropsychiatric lupus

(NPSLE), is a result of poorly defined pathological processes

in the brain of lupus patients. Most of the pathological

processes leading to characteristic of lupus multiple organ

damage, are mediated by autoantibodies and autoantibodies

containing complexes. In our mouse model of NPSLE a subset

of such autoantibodies, anti-dsDNA antibodies cross-reactive

with NMDA receptor (DNRAbs) mediate acute neuronal

damage and subsequent long-term alteration in neuronal

arborization and synaptic density, leading to spatial memory

impairment. Of interest, DNRAbs are associated with spatial

memory impairment in lupus patients. We demonstrated a

critical role of activated microglia and C1q in this pathology,

as the pathology does not occur in C1Q-/- mice, or in mice

depleted of microglia. More importantly, we showed in the

mouse model, that captopril and perindopril, both centrally

acting angiotensin converting enzyme (ACE) inhibitors, can

suppress microglia activation and preserve neuronal integrity

and function, including cognitive performance.

ACE inhibitors are widely used to control hypertension and

are usually well tolerated. This opens the opportunity to

consider the use ACE inhibitors in clinical trials to improve

cognitive impairment in NPSLE patients.

Current studies are undertaken to learn more about the

mechanisms of neuronal injury and of complement and

microglia involvement in these processes.

Speaker Biography

Czeslawa Kowal has completed her PhD from The Institute of Organic

Chemistry of the Polish Academy of Sciences, Warsaw, Poland. She is

associate professor of The Feinstein Institute for Medical Research and

Zucker School of Medicine at Hofstra Northwell, USA. She has over 40

publications that have been cited over 1500 times, and her publication

H-index is 16.