cns-2019-posters-abstracts

2 / 10

Page 39
Notes:
June 10-11, 2019 | Edinburgh, Scotland
Central Nervous System and Therapeutics
2nd International Conference on
Journal of Neurology and Neurorehabilitation Research | Volume 4
allied
academies
Microelectrode recording and deep Brain Stimulation
Amal Mokeem
King Faisal Specialist Hospital & Research center/Riyadh, KSA
Introduction: Microelectrode recording (MER) Defined as
Neurophysiological Technique that detect and amplifies the
activity of Individual Single Neural Units.
Mechanism of Deep Brain Stimulation (DBS):
• HFS suppresses the activity
• of STN, STN neurons discharge spontaneously at a
frequency of ~ 20 Hz.
• PD they became hyperactive with an average firing ~
40Hz. DBS HFS at >100Hz, STN will increase firing during
the initial stimulation period after which they will fail
to respond secondary to inactivation of Na+ channels,
result in synaptic inhibition.
• This stimulation induced activation of inhibitory
presynaptic terminals result reduction of pathologic
activity and its transmission, and subsequent
improvement in information processing high likely
responsible for amelioration of motor symptoms during
DBS
The Food and Drug Administration (FDA) approved DBS as a
treatment for:
• Essential tremor in 1999
• Parkinson's disease in 2002
• Dystonia in 2003
Methods: Patients selection criteria is important.
A number of stimulation techniques may be performed
during movement disorder surgery.Used either:
To asses’ side effect (proximity to structures wish to avoid) To
assess the potential clinical effect of chronic stimulation.
Conclusion: Deep Brain Stimulation (DBS) is safe procedure.
It is safety Greatly depend on:
The quality of the instruments.
The method of stereotactic planning.
The experience of the surgical and neurophysiology team.
Complication of Deep Brain Stimulation (DBS) could be
Numbness, tingling, Symptomatic subdural hemorrhages,
Infection, Hardware issues.
Speaker Biography
Amal Mokeem, is at present a consultant Clinical Neurophysiologist
in the department of Neurosciences at King Faisal Specialist Hospital/
Riyadh. Assistance professor at Al-Faisal University. Program director
of Clinical Neurophysiology fellowship program and technologist
training program. She is honored to be the first Saudi Neurophysiologist
physician experienced in the field of deep brain stimulation (DBS) and
intra-operative micro-electrode recording (MER) in the kingdom of
Saudi Arabia.
e: