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June 12-13, 2019 | Edinburgh, Scotland
Pediatrics and Clinical Pediatrics
2
nd
World Congress on
Current Pediatric Research | Volume: 23
Primary antibiotics resistance of Helicobacter pylori isolated from Peptic Ulcer
children at National Pediatric Hospital, Hanoi, Vietnam
Thi Ut Nguyen, Thanh hai le, Thu Hien pham
and
Thi Bich Ngoc Hoang
National Pediatric Hospital, Vietnam
S
tatement of the Problem:
Helicobacter pylori (H. pylori)
is the major cause of peptic ulcer disease (PUD) in
children. Treatment of
H. pylori
induced PUD is challenging
due to antibiotics resistance. The objective of this study
is to evaluate the prevalence of antibiotic resistance in
H. pylori
strain isolated from PDU children in National
Pediatric hospital in 2017 in Vietnam. Methodology &
Theoretical Orientation: 165 children had symptoms of
gastro-duodenal disease with no history of eradication
of
H. pylori
, were included in the present study. By
gastric endoscopy, we performed biopsy, and dyed
H.
pylori
shed for histopathology,. We conduct
H. pylori
culture to examine antibiotic resistance of
H. pylori
to
clarithromycin, levofloxacin, amoxicillin, tetracycline
and metronidazole. were performed according to a
standardized protocol using Etest strips The study was
conducted from January 2017 through December 2017 in
National hospital of Pediatrics, Hanoi, Vietnam. Findings:
We observed 163 strains (98.8%)with primary antibiotic-
resistant
H. pylori
. Resistance to clarithromycin was the
most predominant with the highest proportion of 97%.
Resistance to amoxicillin, metronidazole, levofloxacin
and tetracycline were 51.5%, 66.1%, 9.7% and 0.6 %,
respectively. Co-resistance to 2 antibiotics was observed
among 64.8% forclarithromycin and metronidazole, and
31.5% for amoxicillin and metronidazole. Triple resistance
to amoxicillin, clarithromycin, and tetracycline was as low
as 0.6%. Since primary antibiotic resistance of
H. pylori
children on peptic ulcers are common, it is necessary to
the use antimicrobial susceptibility test before prescribing
antibiotics in order to improve the effectiveness of
H.
pylori
eradication.
Speaker Biography
Thi Ut Nguyen is a pediatrician. She is working as gastroenterologist
in Gastroenterology department of the National Pediatric Hospital.
She has conducted several studies on
Helicobacter pylori
antibiotics
resistance and virulence of gastritis and peptic ulcer among children.
e:
nguyenvuthuyduong2003@gmail.comThi Ut Nguyen et al., Current Pediatric Research, Volume 23
ISSN: 0971-9032