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Journal of Nutrition and Human Health | Volume 3
J Nutr Hum Health, Volume 3
November 21-22, 2019 | Singapore
Clinical Nutrition and Fitness
17
th
International Conference on
Effects of toss jute (
Corchurus olitorius
) and yellow tassel (
Emilia coccinea
) vegetables
extracts on the lipid profile and blood glucose level of alloxan induced diabetic rats
Igbatim Clement
University of Nigeria, Nigeria
T
he study examined the effects of the aqueous extracts two
leafy vegetables (
Corchurus olitorius
and
Emilia coccinea
)
on the lipid profile and blood glucose level of alloxan induced
adult male diabetic rats. The study adopted the experimental
design. The tender leaves of the two leafy vegetables were
cultivated from farmlands in Mbamo ward, Katsina-Ala,
Benue State. The leaves were sorted, rinsed with portable
water, shade dried and pulverized. The experimental animals
for this study were healthy adult male albino wistar rats
weighing between 100-200g. The acute toxicity and mean
lethal dose (LD50) of the aqueous extracts was determined
using a total of 18mice for the test. The experimental animals
were fed water and rat chow ad libitum. The rats were
randomly divided into 7 groups of five rats each made up of
six (6) test groups and a control group. Rats in group 1 served
as a control group of normal rats fed rat chow and distilled
water only. Groups 2 - 3, 4-5 and 6-7 were diabetic groups
fed rat chow and administered orally 100, 200 and 300 mg/
kg body weight of the various vegetable extracts, respectively
early in the morning for the 14 days feeding trial. The rats in
each group were induced of diabetes using alloxan on the 6th
day and the results collected from the samples served as the
baseline data. The individual weights of the rats were taken
at the beginning of the experiment and at the end of the
experiment to determine the weight gain. The blood samples
collected before the feeding trial and after the treatment
were subjected to biochemical analysis. The data obtained
from the biological studies were analysed using the Statistical
Product and Service Solutions (SPSS) version 21.0 computer
software package. The 100mg
E.coccinea
group had the
highest (10.7%) increase in weight. The extracts were able to
significantly (p˂0.05) lower the blood glucose relative to the
control. The 300 mg
E.coccinea
extracts showed the highest
(43.1%)decreaseintotalcholesterol.Allthevegetableextracts
at various levels of supplementation showed a reduction in
triglycerides. The 200mg
C.olitorius
group showed the highest
(40.2%) reduction in triglycerides level (p˂0.05). The 300mg
E.coccinea
group had the highest (13.6%) increase in HDL-c.
Vegetable extracts supplementation in all groups showed
a decrease in LDL-c levels (p˃0.05). The 200mg C. olitorius
and 300mg
E.coccinea
had the highest (40.3%) decrease in
VLDL-c. There was a decrease in the % difference of the ratio
of LDL-c/HDL-c in all the groups except 200mg/kg
C.olitorius
(42.9%) that rather showed an increase. All the values in
the TC/HDL ratio were not above 5. There was an observed
% decrease in the total protein in all groups. The 200mg
C.
olitorius
group showed the highest (35.7%) overall decrease
in albumin levels (p˂0.05). There was an observed%decrease
in the activities of AST, ALT and ALP for all the groups. This
study has revealed that, these vegetables have properties
that were able to reduce blood glucose level and ameliorate
the lipid profile in rats.
Speaker Biography
Igbatim Clement completed his Ph.D. in Human Nutrition and Dietetics from
the University of Nigeria Nsukka, Nigeria at the age of 45 years. He is a Chief
Standards Officer with the Standards Organisation of Nigeria. He has over
ten publications in local and international journals. He is a researcher and
consultant Nutritionist.
e:
clemigbatim@gmail.com