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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3 Chemistry World 2017
November 13-15, 2017 Athens, Greece
7th World Congress on
Chemistry
Philippe C Gros, J Biotech and Phyto 2017
Bimetallic reagents for synthesis of
functional heterocyclic compounds
Functional heterocyclic derivatives are compounds
of great importance with a wide spectrum of
applications in e.g. biology, catalysis, supramolecular
chemistry or energy conversion. The development of
emerging technologies increases the need for more and
more sophisticated heteroaromatic compounds drawing
the synthetic chemist to design selective and applicable
functionalization routes. Pyridine derivatives belong
to one of the most important family and our group is
focussing on chemo and regioselective routes to pyridyl
organometallics (lithium [1] and ate complexes [2]).
These intermediates are subsequently used in coupling
reactions or enantioselective additions. The conference
will focus on the preparation of a range of pyridyl
organometallics from lab-made metalation reagents,
their characterization and use for the synthesis of
functional poly- and chiral heteroaromatic compounds.
Recent Publications
1. P C Gros, Y Fort (2002) nbuli/lithium aminoalkoxide
aggregates: new and promising lithiating agents
for pyridine derivatives. Eur. J. Org. Chem.,
2002(20):3375-3383.
2. P C Gros, Y Fort (2009) Title of the Article. Eur. J.
Org. Chem. Volume. 4199-4209.
3. H K Khartabil, P C Gros, Y Fort, M F Ruiz López
(2010) Metalation of pyridines with nbuli−li−
aminoalkoxide mixed aggregates: the origin of
chemoselectivity. J. Am. Chem Soc. 132(7):2410-
2416.
4. Francos J, Gros P C, Kennedy A, O'Hara C
(2015) Structural Studies of (rac)-BIPHEN
organomagnesiates and intermediates in the
halogen–metal exchange of 2-bromopyridine
Organometallics. 34(11):2550-2557.
5. Tilly D, Chevallier F, Mongin F, Gros P C (2014)
Bimetallic combinations for dehalogenative
metalation involving organic compounds. Chem.
Rev. 114(2):1207-1257.
Biography
Philippe C Gros studied Chemistry at the University of Lyon (France) and obtained
his PhD in 1992. After two years as a Postdoctoral Fellow, he entered CNRS in
1994 and became Research Director in 2006. He is now first-class Research
Director and Head of CNRS UMR SRSMC in Nancy, France (120 persons). He
has published more than 100 peer-reviewed papers (h index 26) and coordinated
several research programs. His research interests include the design of new
metallating agents for functionalization of heterocycles, transition metal-catalyzed
cross-couplings for ligand synthesis, and the design of photo- and electroactive
organometallic materials.
Philippe.gros
Philippe C Gros
SRSMC - University of Lorraine-CNRS, France