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S e p t e m b e r 1 0 - 1 1 , 2 0 1 8 | D u b l i n , I r e l a n d
Cell and Gene Therapy 2018 & Clinical Microbiology Congress 2018
Note:
Page 7
allied
academies
CLINICAL AND MEDICAL MICROBIOLOGY
CELL AND GENE THERAPY
&
World Congress on
International Conference on
Joint Event on
Biomedical Research
|
ISSN: 0976-1683
|
Volume 29
Vipin K Rastogi, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C3-006
CURRENT CHALLENGES TO
BIOTERRORISM RESPONSE
B
ioterrorism was reckoned to be a stark reality since mailing of
Bacillus
anthracis
spores via USPS, right after 2001. Spores of
B anthracis
, cause
anthrax disease in animals and humans, and the infectious dose varies from
1-10 to fewthousands. In theevent of a large-scalespore release, earlydetection
and delineating the contaminated zones is a significant challenge. Further,
rapid and effective cleanup of contaminated sites, including building interiors,
is paramount to minimizing the consequence of BW release, and restoration of
normalcy. For past 15 years, our lab has been focused on both early detection
of bacterial pathogens and ricin toxin, and BW decontamination research. With
respect to early BW detection, field detection using molecular approaches is
compromised by false-negative and false-positive outcome. Further, use of
hand-held assays (lateral flow tickets) must contend with high limit of detection
(10,000-50,000). In the event of wide-area release, rapid sampling and sampling
efficiency from diverse exterior (porous and non-porous) surfaces is a critical
challenge. Some of our recent R&D and that of our collaborators at US EPA has
evaluated effectiveness of both, liquid disinfectants and gaseous fumigants,
on diverse range of surfaces. For example, peroxide-based approaches will be
ineffective on concrete and free-chlorine-based approaches will be ineffective
on wood like structures. Some of our recent work on development of a novel
approach, DeconGel for BW decontamination will be presented. Based on our
recent study, decontamination of vertical contaminated surfaces was found to
be only partially effective, when liquid disinfectants were applied.
Biography
Vipin K Rastogi is a Senior Research Biologist
with Research and Technology Directorate at US
Army - Edgewood Chemical Biological Center, at
Aberdeen Proving Grounds, Maryland, USA. He has
been conducting R&D for over 23 years in Chemi-
cal-Biological Warfare Agents defense area, specif-
ically their detection and decontamination. Before
joining APG, he was Assistant Research Professor
at Texas A&M University, College Park, Texas. He
earned his BSc and MSc in Plant Sciences from
Delhi University, India, and earned his PhD from
McMaster University, Hamilton, Canada.
vipin.k.rastogi.civ@mail.milVipin K Rastogi
US Army – Edgewood Chemical
Biological Center, USA