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Adv cel sci tissue cul 2017 | Volume 1 Issue 2
Cell Science, Stem Cell Research &
Pharmacological Regenerative Medicine
November 29-30, 2017 | Atlanta, USA
Annual Congress on
Introduction:
There are increasing evidences that favor
the prenatal beginning of schizophrenia. These evidences
point toward intra-uterine environmental factors that
act specifically during the second pregnancy trimester
producing a direct damage of the brain of the fetus. The
current available technology doesn’t allow observing what
is happening at cellular level since the human brain is not
exposed to a direct analysis in that stage of the life in subjects
at high risk of developing schizophrenia.
Methods:
In 1977, we began a direct electron microscopic
research of the brain of fetuses at high risk fromschizophrenic
mothers to find differences at cellular level in relation to
controls.
Results:
In these studies, we have observed within the nuclei
of neurons the presence of complete and incomplete viral
particles that reacted in positive form with antibodies to
herpes simplex hominis type I [HSV1] virus and mitochondria
alterations.
Conclusion:
The importance of these findings can have
practical applications in the prevention of the illness keeping
inmind its direct relation to the etiology and physiopathology
of schizophrenia. A study of amniotic fluid cells in women
at risk of having a schizophrenic offspring is considered.
Of being observed the same alterations that those
observed previously in the cells of the brain of the studied
fetuses, it would intend to these women in risk of having
a schizophrenia descendant, previous information of the
results, the voluntary medical interruption of the pregnancy
or an early anti HSV1 viral treatment as preventive measure
of the later development of the illness.
Speaker Biography
Segundo Mesa Castillo worked for 10 years as Specialist in Neurology in the Institute
of Neurology of Havana, Cuba. He has worked in Electron Microscopic Studies
on Schizophrenia for 32 years. He was awarded with the International Price of the
Stanley Foundation Award Program and for the Professional Committee to work as a
Fellowship position in the Laboratory of the Central Nervous System Studies, National
Institute of Neurological Diseases and Stroke under Joseph Gibbs for a period of 6
months, National Institute of Health, Bethesda, Maryland, Washington DC, USA, June
5, 1990. At present, he is a Member of the Scientific Board of the Psychiatric Hospital
of Havana and gives lectures to residents in Psychiatry.
e:
segundo@infomed.sld.cuSegundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
Direct evidence of viral infection and mitochondrial alterations in the brain of
fetuses at high risk for schizophrenia