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Adv cel sci tissue cul 2017 | Volume 1 Issue 2
Cell Science, Stem Cell Research &
Pharmacological Regenerative Medicine
November 29-30, 2017 | Atlanta, USA
Annual Congress on
Spinal cord injury (SCI) can cause chronic neuropathic
pain. Currently, available therapies are inadequate for
SCI-induced neuropathic pain. In the present study, we
investigated the effect of spinal transplantation of mouse
embryonic stem cell-derived oligodendrocyte progenitor
cells (OPCs) on SCI pain using a rat contusion SCI model.
We observed that chronic neuropathic pain was present
on day 7 after SCI and persisted for the entire 56-day
observation period. Spinal transplantation of OPCs enhanced
remyelination in the injured spinal cord and reduced SCI-
induced chronic neuropathic pain. Moreover, we found that
SCI decreased the protein level of neuregulin-1 and ErbB4
in the injured spinal cord and that OPC transplantation
can rescue the spinal expression of both proteins after
SCI. Furthermore, intrathecal injection of neuregulin-1
siRNA, but not the control non-target RNA, reduced OPC
transplantation-produced remyelination and counteracted
the antinociceptive effect of OPC transplantation. Our
results suggest that spinal transplantation of embryonic
stem cell-derived OPCs is an appropriate therapy for SCI pain
and that neuregulin-1/ErbB signaling is involved in central
remyelination under pathological conditions and contributes
to OPC transplantation-mediated alleviation of SCI pain.
Speaker Biography
Feng Tao is an Associate Professor in the Department of Biomedical Sciences at Texas
A&M University College of Dentistry. He received his RO1 award and Independent
Scientist Award from NIH in 2012 and 2014, respectively. He has published more than
40 papers in peer-reviewed professional journals and he is serving as an Editorial Board
Member for some professional journals. He also served as an invited reviewer for NIH
NRCS Study Section, Johns Hopkins ACCM Seed Grant, NSF-sponsored Pilot Funding
at Louisiana State University, Arizona Biomedical Research Commission, Britain Israel
Research and Academic Exchange Partnership Regenerative Medicine Initiative, Wings
for Life Spinal Cord Research Foundation in Austria, Department of Veterans Affairs
Rehabilitation Research and Development Service Spinal Cord Injury and Neuropathic
Pain Panel and The French National Research Agency (ANR) in France.
e:
Feng Tao
Texas A&M University College of Dentistry, USA
Effect of spinal transplantation of embryonic stem cell-derived oligodendrocyte
progenitor cells on spinal cord injury pain