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Journal of Nutrition and Human Health | Volume 2
&
October 29-30, 2018 | London, UK
Joint Event
Nutrition and Fitness
16th International Conference on 3rd World Congress on
Card i o l ogy
Marcela Sorelli Carneiro Ramos
Federal University of ABC, Brazil
Cardiorenal Syndrome: The long road from Kidney to Heart
The number of individuals with kidney disease increases
every year and is a major concern in several countries.
Once the kidney is not functioning properly, with a deficit in
glomerular filtration rate, several hemodynamic factors are
altered, and toxins and molecules start to accumulate in the
bloodstream. Among others, several cytokines and chemokines
increase during kidney disease, consequently impairing other
organs function and leading to renal and cardiac diseases. In
this sense, Cardiorenal Syndrome (CRS) is characterized by
different clinical conditions with an overlap of cardiac and
renal dysfunctions. One subtype of this pathology involves
cardiac hypertrophy and cardiac failure after acute renal
injury (AKI). AKI frequently leads to the development of
chronic kidney disease and may be associated with ischemia
followed by reperfusion (I/R). The knowledge of the cellular
mechanisms involved in CRS are not fully known but permeate
molecular, cellular and functional factors. In this sense, the
present conference aims to contextualize this topic as well as to
present some results regarding the participation of the immune
system in the cardiovascular alterations observed in the CRS.
Speaker Biography
Marcela Sorelli Carneiro Ramos is graduated in Biomedicine (2001), completed a PhD
(2006) and Post-Doctoral (2008) in the Department of Cell Biology and Development of the
Institute of Biomedical Sciences of the University of São Paulo. The research developed in
this period, addressed the role of the Renin-Angiotensin System in the thyroid hormone-
induced cardiac hypertrophy, as well the effect of thyroxine on global gene expression
modulation. Nowadays, the research line aims to study the impact of the inflammatory
response and immune system on the cardiovascular changes observed in the cardiorenal
syndrome.She isanAssociateProfessorattheFederalUniversityofABCandhasexperience
in cell and molecular biology, cardiovascular physiology, inflammation and renal failure.
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