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J u l y 2 3 - 2 4 , 2 0 1 8 | R o m e , I t a l y
Note:
alliedacademies Joint Event on
Cardiology Congress 2018 & Microbe Infection 2018 Biomedical Research | ISSN: 0976-1683 | Volume 29
2nd World Congress on CARDIOLOGY
MICROBIOLOGY AND MICROBIAL INFECTION
&
39th Annual Congress on
Claudia Vuotto et al., Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C1-002
POSSIBLE STRATEGIES TO OVERCOME
DRUG RESISTANCE IN BIOFILM
Claudia Vuotto and Gianfranco Donelli
Fondazione Santa Lucia IRCCS, Microbial Biofilm Laboratory, Italy
Biofilm-growing nosocomial pathogens represent a serious public health
concern. In fact, the biofilm mode of growth is highly relevant in clinical
settings where these microbial communities, displaying higher levels of
antimicrobial resistance, cause several difficult-to-treat chronic infections.
The reduced effectiveness of many antibiotics against bacteria grown as
biofilm is due to the presence of the exopolysaccharide matrix, the reduced
growth rate of microbial cells and the significant increase in the level of
horizontal gene transfer. The relapsing nature of biofilm-related infections
makes increasingly necessary to discover new antimicrobial agents able to
interfere with biofilm formation and maturation, without inducing antibiotic
resistance. This presentation will focus on biofilm resistance in aerobic and
anaerobic species, underlining their response to antibiotics in terms of matrix
production and induction of a viable but non-culturable state. Refractory
medical devices and not-inducing resistance, antibacterial compounds will
be presented as possible anti-biofilm strategies.
Claudia Vuotto is currently working in the Microbial
Bioflim Laboratory and she is also an associate with
Fondazione Santa Lucia IRCCS.
BIOGRAPHY