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allied
academies
Current Trends in Cardiology | Volume: 03
10
th
WORLD HEART CONGRESS
&
6
th
International Congress on
CARDIOLOGY AND CARDIAC SURGERY
December 02-03, Dubai, UAE
Joint event on
Curr Trend Cardiol, Volume: 03
Early identification of cognitive decline in metabolic syndrome
Galya Naydenova Atanasova
Country Medical University of Pleven, Bulgaria
Background
: Metabolic syndrome (MetS) may be a
prodromal manifestation of vascular cognitive impairment.
Diagnosingearlystagesofcerebrovascularpathologycanlead
to prevention and delay of the progression of pathological
conditions such as vascular cognitive impairment.
Objective
: The objective of the study was to investigate
new biomarkers for early diagnosis of MetS and cognitive
decline as a follow-up. A cardiological, neuropsychological
and neurological study was conducted among 75 Bulgarian
participants. Beta amyloid in the blood, procalcitonin
(PCT), NT-proBNP as predictors of cognitive impairment in
patients with metabolic syndrome were identified.
Methods
:
Clinical,
anthropometric,
biochemical,
neuropsychological, cognitive and statistical data
processing. Plasma amyloid beta (Aβ) levels, procalcitonin,
NT-proBNP in MetS were investigated in participants with
MetS and in group of healthy people.
Results
: In the present study, plasma levels of Aβ42 and
Aβ40 were found to be reduced in MetS participants.
Procalcitonin concentration was significantly higher
in males than in females. NT-proBNP was significantly
higher in females than in males (p <0.001). Regression
analysis showed a positive relationship between NT-
proBNP and systolic blood pressure (p <0.001) and fasting
blood glucose (p <0.05). An inverse relation between NT-
proBNP and diastolic blood pressure, waist circumference,
triglycerides, HDL- and LDL cholesterol was found.
Conclusions: There was a positive association between
PCT levels, decreased levels of Aβ42 and Aβ40, as well as
elevated NT-proBNP and cognitive impairment in people
with MetC. A concentration of NT-proBNP of 60 pg / ml or
greater could be an indicator of metabolic abnormalities
and early cognitive decline.
e:
gal_na69@abv.bg