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allied
academies
CANCER THERAPY AND ONCOLOGY
NEUROLOGY AND BRAIN DISORDERS
&
International Conference on
International Conference on
J u n e 2 1 - 2 2 , 2 0 1 8 | O s a k a , J a p a n
Allied Journal of Medical Research
|
Volume 2
Page 30
Joint Event on
Introduction:
Over the past 30 years there has been a significant reduction
in mortality following severe TBI together with improved outcome. This has
been largely due to the use of evidence-based protocols emphasizing the
correction of parameters implicated in secondary brain injury. The main
parameters are cerebral blood flow, cerebral oxygenation and management
of co-morbidities. Neuroinflammation is a well-established secondary
injury mechanism following TBI.
Evolving treatment strategies:
Inspired by success in Parkinson’s and
other neurodegenerative diseases, stem cell based therapy is believed to
provide biobridges, can stabilize blood-brain barrier, reduce the oxidative
stress and provide immunomodulation and neuroprotection. Hyperbaric
oxygen may alleviate secondary insult in TBI through the modulation of the
inflammatory response. Animal studies showed that hyperbaric oxygen
improves neuroplasticity, reduce the inflammatory markers and neuronal
apoptosis following TBI.
Sources of stem cells:
Modulating endogenous stem cells or Cell
transplantation (using exogenous stem cells) from fetal/embryonic, bone
marrow stromal cells, umbilical cord cells or induced pluripotent stem cells
(iPSCs). There is plenty of literature showing good response of stem cell
therapy, mesenchymal stem cells in particular, on the outcome in rat TBI
models. The animal models indicate some vulnerability of the stem cells
to the hostile environment of neuroinflammation, which may limit their
potential
Conclusion:
The resultsalthoughveryencouraging, arestill in the laboratory/
preclinical phase and lots of technical, ethical and logistic issues have to be
solved before shifting to clinical trials. Hyperbaric oxygenation can provide
less hostile microenvironment helping with repair and provide better use of
stem cell induced growth factors.
Biography
Hazem Ahmed Mostafa is an internationally recog-
nized neurosurgeon with over two decades of clinical
and research experience. He has devoted his career
to developing and providing rigorous, comprehensive
and compassionate care to those with cancer, neuro-
logical degenerative diseases and pediatric disorders.
He’s affectionately known as Dr Brain and Spine. He is
a professor in the Department of Neurosurgery at Ain
Shams University, Egypt since 2014. He is a Consultant
of Neurosurgery at his own private clinics NeuroClin-
ic Cairo and Hurghada - Red Sea, Egypt since 2001.
He has dedicated a significant part of his career to
developing innovative educational research with over
33 published research papers in the Egyptian Society
journal. He is an activemember of the Egyptian Society
of Neurological Surgeons since 1997. He is an interna-
tional Faculty at AO Trauma Foundation. He is also an
international fellow member of the Institute of Brain
Chemistry and Human Nutrition (IBCHNUK).
MassAppealPR@gmail.comSTEM CELLS AND HYPERBARIC
OXYGEN THERAPY FOR TBI
MANAGEMENT
Hazem Ahmed Mostafa
Ain Shams University, Egypt
Hazem Ahmed Mostafa, Allied J Med Res 2018, Volume 2