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CANCER STEM CELLS AND
ONCOLOGY RESEARCH
11th International Conference on
Journal of Medical Oncology and Therapeutics | Volume 3
Teresa Pellegrino et al., J Med Oncl Ther 2018, Volume 3
MAGNETIC NANOCRYSTALS AND
MAGNETIC HYPERTHERMIA TO
TACKLE CANCER STEM CELLS
Teresa Pellegrino, Soraia Fernandes, Sabrina Janoschek,
Preethi Bala Balakrishnan and Matilde Todaro
Italian Institute of Technology, Italy
The use of heat to reduce tumor mass is very ancient. Nowadays,
there are several techniques that allow to precisely focalize the
heat in very specific body regions resulting in treatments that are more
efficient and minimize side effects. Magnetic nanoparticles can act
as heat mediators under external magnetic activation in the so-called
magnetic hyperthermia. The field of magnetic hyperthermia has received
a renewed interest since the colloidal syntheses by non-hydrolytic
methods have revealed several merits over conventional wet chemical
hydrolytic processes in terms of controlled size, size distribution and
crystallinity. All these parameters together with nanoparticles solubility
and state of aggregation can affect structural and magnetic properties
of nanomaterials and thus their heat performance. I will first focus on our
recent progress on iron-based nanoparticles as heat mediators. Then, I
will show our ongoing studies aiming at correlate heat effects on cancer
stem cells. I will also report about in vitro hyperthermia experiments
on primary tumor cells to relate nanoparticle geometry to changes of
magnetic hyperthermia performances in tumor cell. Finally, I will show our
preliminary in vivo studies performed with the aim to combine magnetic
hyperthermia and heat-mediated drug release.
Teresa Pellegrino has received her PhD at the
age of 30 years in Chemical synthesis and Na-
noscience in 2005 from the University of Bari,
Italy. Since 2014 she is tenured team leader of
the group of “Nanomaterials for Biomedical Ap-
plications” at the Italian Institute of Technology,
Genoa, Italy. Her current research interests fo-
cus on the development of inorganic nanostruc-
tures for drug delivery, magnetic hyperthermia,
photo-thermal treatment and radiotherapy ap-
plications. She is coauthor of 112 publications
in the field of nanoscience, nanomedicine and
drug delivery systems that have been cited
more than 10000 times, and her H-index is 44.
BIOGRAPHY