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Page 79
CANCER STEM CELLS AND
ONCOLOGY RESEARCH
11
th
International Conference on
Journal of Medical Oncology and Therapeutics
|
Volume 3
IMPACT OF HLA-G
POLYMORPHISM
ON THE OUTCOME
OF ALLOGENEIC
HEMATOPOIETIC STEM
CELLTRANSPLANTATION
FOR METASTATIC RENAL
CELL CARCINOMA
Crocchiolo R
1
, Ringden O
2
, Bay JO
3
, Blaise D
4
,
Omasic B
2
, Mazzi B
1
, Picard C
5
, Trinca S
1
, Bark-
holt L
2
, Peccatori J
1
, Gregori S
6
, Amodio G
6
,
Fleischhauer K
1
, Ciceri F
1
and Bregni M
1
1
San Raffaele Hospital, Italy
2
Karolinska University Hospital, Sweden
3
CHU Clermont Ferrand, France
4
Aix-Marseille University, France
5
San Raffaele Telethon Institute for Gene Therapy, Italy
R
enal cell carcinoma (RCC) is particularly sensitive to
immune intervention. HLA-G, a non-classical HLA class
I molecule with immunomodulatory properties, has been
studied with regard to outcome after hematopoietic stem
cell transplantation (HSCT), in particular the 14 bp inser-
tion/deletion polymorphism in the 3’ untranslated region.
Here we analyzed n=56 patients affected by metastatic
RCC who received an allogeneic HSCT between 1998 and
2006 in Milano, Marseille, Clermont-Ferrand and Stock-
holm. The 14 bp polymorphism was analyzed in correlation
with overall survival (OS), PFS, acute and chronic GvHD.
With a median follow-up of 13 years, a trend towards better
outcome was observed when homozygosity for the 14bp-
del allele was present: multivariate hazard ratio was 0.50
(95% confidence interval (CI): 0.23-1.13; P=0.10) and 0.57
(95% CI: 0.26-1.26; P=0.17) for OS and PFS, respectively,
when 14bp-del/del was compared with 14bp-ins/X. Fur-
ther exploratory analysis revealed a significant association
between T/C at p3003 and improved OS (P=0.05) and PFS
J Med Oncl Ther 2018, Volume 3
(P=0.006) compared with T/T. To our knowledge this is the
first study on HLA-G and outcome after HSCT for a solid ma-
lignancy. After a coordinated multicenter study, we found that
the more tolerogenic polymorphisms (14bp-del/del) is associ-
ated with better PFS and OS. The finding on p3003 deserves
further investigation.
roberto.crocchiolo@gmail.com