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Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
This work entails the development of combined
micro- and nanoparticulate systems for lung delivery
of therapeutic macromolecules, meeting the specific
delivery requirements of the lung for efficient outcomes.
The proposed micro/nanostructured systems comprised
biopolymers (e.g., chitosan, hyaluronic acid), a gelling anion,
a protein, and a sugar used as a drying adjuvant. The protein
was nanoencapsulated in polymeric matrices, followed
by microencapsulation by spray drying in the presence
of the drying adjuvant, resulting in micro-scale powders
with adequate aerodynamic and morphological features.
Extensive physicochemical, elemental, structural and thermal
investigations were pursued, with emphasis being placed
on structural modifications and interactions of the protein/
carrier system, at a molecular level. Afterwards, intratracheal
administration of the formulations was performed in
rats. Overall, studies revealed the non-invasiveness
of the fabrication techniques to the macromolecule.
Moreover, they confirmed the advantageous strategy of
macromolecule nanoencapsulation in polymeric matrices
prior to transformation into dry powders. These findings
corroborated the in vivo data which showed a significant
biological effect, as compared to the controls, highlighting
the great potential of the developed systems for lung delivery
of macromolecules intended for systemic or local effects.
Speaker Biography
Sonia Al-Qadi has completed her PhD in Pharmaceutical Technology from the
University of Santiago de Compostela in Spain. Then, she pursued two Post-doctoral
trainings in Denmark. She also worked as an Assistant Professor at the Faculties of
Pharmacy in the Middle-East. Her research interests are focused on nano-drug delivery
systems, biomaterials and macromolecules. She has won the Research Fellowships of
Schlumberger Foundation and the Alexander von Humboldt.
e:
Inhalable micro/nano-structured systems for macromolecular drug delivery
Sonia Al-Qadi
University of Santiago de Compostela, Spain