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Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
Ceramides are composed of a sphingoid base attached to
a fatty acid via an amide bond. These lipids serve both a
structural role in membranes and an intracellular signaling
role within a cell. Ceramide is a natural molecule that targets
discrete kinases and signaling pathways linked to proliferation
and/or survival. Due to its potent regulation of cell growth,
differentiation, and death, ceramide has been identified as
a putative therapeutic agent in cancer and cardiovascular
disease. The use of ceramide to inhibit Akt signaling is a novel
approach under preclinical evaluation. Ceramide targets the
PI3K/Akt pathway through dephosphorylation of Akt, leading to
increased cytotoxicity and cell apoptosis when in combination
with another chemotherapeutics, can enhance cell death.
An obstacle that has limited clinical use of ceramide is its
hydrophobicity, which can be overcome by packaging it into a
nanoliposomal formulation for systemic delivery. Hydrophilic
drugs can be entrapped in the aqueous compartment, while
the lipid bilayer can be utilized to incorporate hydrophobic
drugs. Associating a drug with liposome markedly changes
its pharmacokinetic properties and lowers systemic toxicity;
furthermore, the drug is prevented form early degradation
and/or inactivation in circulation. This presentation discusses
the role of ceramides in the formulation of liposomes for the
delivery of model anti-cancer drugs such as doxorubicin and
daunorubicin. The synergistic function of ceramide based
liposomal formulations in melanoma, breast and prostate
cancers will be discussed
Speaker Biography
Jay Babu Ramapuram has completed his PhD from Indian Institute of Technology,
Varanasi, India. He is the Professor in the Dept. of Drug Discovery and Development
at Auburn University, USA. He has over 80 publications that have been cited over 1300
times, and his publication H-index is 21 and has been serving as an Editorial Board
Member of reputed Journals in his research area.
e:
Jay Babu Ramapuram
Auburn University, USA
Ceramides based liposomes for melanoma treatment