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May 20-21, 2019 | Vienna, Austria
Biomaterials and Nanomaterials &
Materials Physics and Materials Science
2
nd
International Conference on
Page 23
Journal of Materials Science and Nanotechnology | Volume 3
O
ptical imaging-guided cancer therapy with multi-
functional nanoparticles are critical for early detection
and treatment of cancers. Two-photon excitation (2PE) based
optical imaging and phototherapy have unique advantages
such as 3-D selectivity and deep tissue penetration, compared
to their one-photon counterparts. Photodynamic therapy
(PDT) is noninvasive cancer therapy technique by using
combination of light and photosensitizers. Conventional
photosensitizers have limited two-photon absorption
efficiency and lack of simultaneous imaging capability.
Nano-photosensitizers are attractive due to their potential
multifunctional capability, which allows integration of
efficient Nano-photosensitizers with specific targeting and
2PE fluorescence imaging capabilities to allow imaging-guided
PDT with high selectivity. In the last decade, our group have
been actively working on development of nanocomposite
materials with enhanced two-photon optical properties
for biomedical applications. Two different strategies were
utilized to develop nanomaterials with enhanced two-photon
properties. One method is based on energy transfer from
conjugated polymers that have large two-photon absorption
cross sections. We have used conjugated polymers as two-
photon light harvesting materials to develop various schemes
for two-photon sensing, imaging and photodynamic therapy,
with efficiency improved by up to 1000 times. The second
approach is based on plasmon resonance enhancement.
Noble metal nanoparticles are known to display interesting
properties of Plasmon resonance, which could be utilized to
enhance linear and nonlinear optical properties of nearby
chromophores (extrinsic) andmetal nanoparticles themselves
(intrinsic). We have developed various plasmon engineered
nanocomposites with significantly enhanced two-photon
optical properties, which can act as highly efficient agents for
two-photon excitation based optical imaging guided therapy.
Speaker Biography
Qing Hua Xu has completed his PhD in 2001 fromUniversity of California
at Berkeley, USA. He is currently an associate professor in department
of chemistry, National University of Singapore. He has published
over 190 publications that have been cited over 7000 times, and his
publication H-index is 49.
e:
chmxqh@nus.edu.sgQing Hua Xu
National University of Singapore, Singapore
Multifunctional nanoparticles for simultaneous two-photon imaging
and phototherapy