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Page 38
Biomaterials Congress 2019
Materials Science and Nanotechnology | Volume 3
June 19-20, 2019 | Dublin, Ireland
OF EXCELLENCE
IN INTERNATIONAL
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BIOMATERIALS,
CELLULAR AND TISSUE ENGINEERING
3
rd
International Conference on
Mater Sci Nanotechnol 2019, Volume 3
MECHANICALLY RESISTANT, BIODEGRADABLE PVA/CA DRESSINGS FUNCTIONALIZED
WITH LL37 PEPTIDE REDUCE MICROBIAL BURDEN
Helena P Felgueiras
University of Minho, Portugal
T
ypically, acute wound healing is a well-organized process that evolves in a predictable amount of time.
Chronic wounds (CW) result from gradual tissue degradation, and are characterized by defective cell ma-
trix, high bacteria counts, prolonged inflammation and moisture imbalance. Antimicrobial dressings, that com-
bine dressing and antibiotics, have been suggested as potential strategies to treat CW. However, the rising
of antibiotic-resistant pathogens has turned these systems obsolete, revealing antimicrobial-peptides (AMPs),
which display a broad spectrum of activity against pathogens and act rapidly at multiple sites within microbial
cells, as viable alternatives. Methodology: In this work, poly(vinyl alcohol) (PVA) and cellulose-acetate (CA) were
prepared via casting/phase-inversion method in the form of films. Different PVA/CA ratios were tested. Their
mechanical, thermal and biodegradation profiles were followed. The films’ capacity to absorb exudates was
also determined. Films were functionalized with LL37 peptide. This AMP is endowed with immunoregulatory
abilities, with great potential for wound healing, and important antimicrobial features.