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Page 37
Biomaterials Congress 2019
Materials Science and Nanotechnology | Volume 3
June 19-20, 2019 | Dublin, Ireland
OF EXCELLENCE
IN INTERNATIONAL
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BIOMATERIALS,
CELLULAR AND TISSUE ENGINEERING
3
rd
International Conference on
Mater Sci Nanotechnol 2019, Volume 3
SCAFFOLDS WITH BG 45S5 AND CROSS-LINKED SILK
David Don López
University of Santiago de Compostela, Spain
B
ioglass is the first invented bioactive glass, also known as 45S5, an important family of ceramic that are used
to regenerate bone tissue. Although it has been used in many cases, when it is sintered to obtain a solid
piece, this glass transforms into crystal structure and it is not a glass anymore with and presents a notorious
decrease of its bioactivity. In order to avoid this problem, a new approach has been developed with the inclu-
sion of silk as a polymer in the inner structure. Silk is a widely used biomaterial that can help the proliferation of
bone cells. The present study is focused in obtain scaffolds with BG 45S5 and crosslinked silk, that acts as a net
holding the bioactive glass particles. To process this material, a freeze casting technique has been selected, as
it is possible to create high porous scaffolds with a high interconnected porosity with this technique. The ob-
tained samples were physically, chemically and biologically characterized, obtaining a complete recover of the
bone tissue in an in vivo experiment during 10 weeks in a rabbit skull. Next steps are focused in conform this
same materials scaffolds through a 3D printer, that will allow to create samples with a desired shape and size. A
new start-up company is being created, Mat Print that will commercialize 3D printed ceramic samples and it is
being developed from the research carried out from the Instituto de Cerámica de Galicia.