alzheimers-2019-scientifictracks

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allied

academies

International Conference on

Alzheimers Disease and Dementia

November 25-26, 2019 | Frankfurt, Germany

Journal of Psychology and Cognition | Volume: 04

J Psychol Cognition, Volume: 04

Determination of the role of HA, HYAL and HA- Receptor Expression in a rat model

of Middle Cerebral Artery Occlusion

Ahmed Al Qteishat

Al-Ahliyya Amman University, Jordan

yaluronan (HA), a component of the extracellular

matrix, has been implicated in regulating angiogenesis

and cell proliferation, migration, and signaling. We used

the rat MCAO to show hyaluronan accumulation in

stroke-affected areas. Using RT-PCR and Western blotting

we showed up-regulation of hyaluronidase-1 and 2

between 1h and 21 days after stroke. Hyaluronidase-1

was up regulated earlier than hyaluronidase-2. RHAMM

and CD44 receptors were also increased after stroke.

Immunohistochemistry results, showed an association of

hyaluronidases1/2 and hyaladherins with neurons in the

infarcted and peri-infarcted regions and hyaluronidase-1

with microvessels. HA synthesis and degradation in the

stroke hemisphere might have an impact on neuronal

survival, angiogenesis and general tissue remodeling after

stroke.

Biography

Ahmed Al Qteishat is currently working as an associate professor in Al-

Ahliyya Amman University, Amman, Jordan. He studied his Bachelor

degree in the Applied Science University. He completed his Ph.D in

Manchester Metropolitan University.