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Journal of biomedical imaging and bioengineering
Volume 1, Issue 2
October 05-06, 2017 | Las Vegas, USA
allied
academies
3D PRINTING CONFERENCE INNOVATION,
MODELLING, APPLICATION & IMPLEMENTATION
I
n recent years, Additive Manufacturing (also known as
3D printing) processes such as Selective Laser Sintering
(SLS) has shown great prominence in the biomedical field,
and several researchers have conducted studies showing
a wide diversity of materials and applications, such as the
additive manufacturing of medical products, scaffolds and
drug delivery devices (DDDs). The increase in the number of
people affected by genetic and infectious diseases resistant
to conventional treatments has led to the need to develop
new medical treatments by understanding the mechanisms
of action and the targets of pharmacological action at
the molecular level. As well as, to develop more specific
transport systems for existing hydrophobic and hydrophilic
drugs in order to increase the therapeutic efficacy of these
drugs. Implantable drug delivery devices (DDDs) technology
offer several advantages over conventional methods such
as oral or parenteral dosage form, allowing specific drug
administration at the target site, minimizing potential side
effects. This therapy may provide controlled release of a
medicine for acute and chronic treatments.
Hormone cancer therapy is a form of systemic therapy that
works to add, block or remove hormones from the body to
slow or stop the growth of cancer cells. The use of hormone
therapy in combination with other cancer treatments, such
as chemotherapy and radiation therapy can be applied to
fight various forms of cancer. Progesterone consistently
suppressed the expression of genes required for cell
proliferation and metastasis and increased the expression of
many tumor-suppressor genes. The hormone therapy using
progesterone in the treatment of different types of cancer,
such as breast, ovarian, uterus and prostate cancers have
been investigated.
Chondrosarcoma is a malignant cartilaginous tumor. It is
the second largest group of primary bone tumors. Highest
prevalence is found between the fourth and sixth decade,
with an equal male to female ratio. Approximately 90% of
chondrosarcoma are described as conventional type. They
arise centrally in the metaphysial region of long bones, but
can also develop in flat bones such as pelvis, rib and scapula.
A minority (up to 15%) of conventional chondrosarcoma
develops from the surface of bone as a result of malignant
transformation within the cartilage cap of a pre-existent
osteochondroma and is therefore called secondary or
peripheral chondrosarcoma. For all grades of non-metastatic
chondrosarcoma en-block resection offers the best
recurrence free survival, surgical management is related
to grade, type and site. Chemotherapy is possibly effective
in mesenchymal chondrosarcoma, and of uncertain value
in dedifferentiated chondrosarcoma. Local drug delivery
systems can be an option to the cartilage-bone cancer
treatment. Minimally invasive, intratumoral strategies
for the treatment of solid tumors promise to substantially
improve the therapeutic outcomes for many cancers.
SLS is a good alternative to controlling the porosity of
bio-inert and bio-absorbable polymeric matrices and,
consequently, control the drug release of implantable DDDs.
In this study, DDDs with polymeric matrices, hydrophilic and
hydrophobic drugs for cancer therapy were manufactured
and characterized. The structure and properties of the
manufactured DDDs were evaluated and correlated with the
processing conditions.
Speaker Biography
Gean Vitor Salmoria has a Chemistry Graduation and MSc from the Federal University
of Santa Catarina (UFSC) in Brazil and Microwave Processing PhD from the Institut
National Polytechnique de Toulouse in France. He is a specialist in eletrothermal
processes and organic material chemistry. His research interest includes fabrication
using microwave, ultra-violet and infra-red lasers, additive manufacturing and rapid
tooling for extrusion and injection molding applied to automobile, aerospace and
biomedical industries. He is a Professor on design with plastics at the Mechanical
Engineering Department of UFSC since 2001. He has published more than 70 papers in
reputed journals and has been serving as an editorial board member of the Journal of
Advanced Manufacturing Research.
e:
gean.salmoria@ufsc.brGean Vitor Salmoria
Federal University of Santa Catarina, Brazil
3D laser printing of implantable drug delivery for cancer treatment