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Journal of Trauma and Critical Care | Volume 3
Joint Event
February 21-22, 2019 | Paris, France
Microbiology & Applied
Microbiology
2
nd
International Conference on
World Congress on
Wound Care, Tissue Repair
and Regenerative Medicine
&
R
ecently, extensive research on higher basidiomycetous
fungi has markedly increased, mainly due to their potential
use in a variety of biotechnological applications, particularly
for the production of food, enzymes, dietary supplements,
and pharmaceutical compounds. This presentation integrates
recent literature and our own data on the physiology of
bioactive compounds production, focusing on the common
characteristics and unique properties of individual fungi as
well as on several approaches providing enhanced yields of
target products. Among basidiomycetes, so called medicinal
mushrooms constitute a rich source of bioactive compounds
exhibiting antitumor, antidiabetic, immunomodulating,
antioxidant, antimicrobial andmany other properties. However,
the production of antioxidants, lectins and exo-polysaccharides
is species- and even strain-dependent and some nutrient
supplements regulate bioactive compounds synthesis although
their effect is very specific depending on fungi physiological
peculiarities.
An overview of available data underlines that the regulation of
lignocellulose-deconstructing enzymes production appears to
be subject to complex interplay of nutritional, environmental,
and genetic factors. To correctly evaluate the fungi biosynthetic
potential and to maximally express cellulase, laccase, lignin
and manganese peroxidase activities a fungus specific carbon
source/lignocellulosic substrate, an appropriate enzyme
synthesis inducer, other required factors should be elucidated.
Data received indicate that lignocellulosic growth substrates,
some of which contain significant concentrations of soluble
carbohydrates and inducers, play a crucial role in enzyme
production. Moreover, co-culture of compatible fungi may be
an appropriate approach to enhance their biosynthetic activity
and yield of target products.
Finally, a brief outline of efforts to exploit the whiterot fungi
potential for the bioremediation of polluted areas and for
sustainable processing of renewable biomass into spectrum of
marketable products and energy is also presented.
Speaker Biography
Vladimir Elisashvili is a director of the Animal Husbandry and Feed Production Institute
of the Agricultural University of Georgia. In 1974, he obtained his PhD in microbiology
at the Saint Petersburg (Leningrad) State University. Then, he continued his work at
the chair of microbiology as a scientist and assistant professor. In 1983, he joined
the Durmishidze Institute of Biochemistry and Biotechnology, Tbilisi, Georgia and
in 1993, he obtained the Doctor of biological sciences degree in biochemistry. In
1976/77, he obtained a postdoc position at the Institute of Molecular Biology, Paris
VII, France. In 2001-2006, he worked at the Free University of Brussels and in two
biotechnological companies in Israel. He has over 190 publications and supervised 21
PhD theses. He is serving as an editorial board member of three reputed Journals.
e:
v.elisashvili@agruni.edu.geVladimir Elisashvili
Kachlishvili E, Asatiani M D, Khardziani T
and
Metreveli E
Agricultural University of Georgia, Georgia
Basidiomycetes as a multi-purpose cell factory: Current status and perspectives
Vladimir Elisashvili et al.
,
J Trauma Crit Care, Volume 3
DOI: 10.4066/2591-7358-C1-001