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Dermatol Res Skin Care 2017 | Volume 1 Issue 1
World
Dermatologist Summit and Skin Care Expo
October 30-31, 2017 | Toronto, Canada
Introduction:
Psoriatic patients, especially with psoriatic
arthritis (PsA), are more prone to metabolic disorders and
involving the eyes.
Aim:
The aim of this study was presentation adalimumab
efficacy of several aspects of psoriasis and its comorbidities.
Material & Methods:
We present a 48-year-old male patient
with severe plaque psoriasis and PsA who developed uveitis
with cystoid macular oedema in the right eye. The patient was
obese although bariatric surgery eight years earlier produced
some weight loss with remission of diabetes and hypertension.
Results & Discussion:
The patient had been previously treated
with systemic treatment with no improvement in PsA symptoms
and skin lesions but rapidly responded to adalimumab. At week
8, the patient achieved the PASI 75, with no joint pain and
normal macular architecture. At week 16, there was an incident
of atrial fibrillation followedbya transient ischaemicattack (TIA).
The TIA subsided after intravenous fluids and antithrombotic
treatment although acute urticaria developed after the first
dose of acetylsalicylic acid. Adalimumab treatment was not
stopped and the patient’s condition continued to improve.
Conclusions:
After careful consideration of the patient’s
underlying and comorbid conditions and previous treatment
failures, adalimumab was instituted and continued since its
efficacy in psoriasis and PsA is well-documented; obesity is
not thought to affect its effectiveness; inuveitis adalimumab
acts quickly and induces long-term remission and a significant
improvement of hemostasis and fibrynolytic balance has been
observed in patients on TNF-α inhibitors and adalimumab could
be continued after the TIA.
Speaker Biography
Agnieszka Owczarczyk-Saczonek is Assistant Professor of the Department of
Dermatology, Sexually Transmitted Diseases and Clinical Immunology at The
University of Warmia and Mazury in Olsztyn. She was appointed as the Consultant
in dermatology and veneorogy of Warmian-Masurian Voivodeship in 2013. Moreover
she is a Member of the Polish Society of Dermatology, a Member of the Association
of Aesthetic Dermatology, and a Member of the European Academy of Dermatology
and Venereology.
e:
aganek@wp.plAgnieszka Owczarczyk-Saczonek
University of Warmia and Mazury in Olsztyn, Poland
Plaque psoriasis and psoriatic arthritis associated with uveitis and cystoid macular
edema treated with adalimumab: A case report and literature review