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allied
academies
September 20-21, 2017 | Philadelphia, USA
Global summit on
TUBERCULOSIS AND LUNG DISEASE
Int J Respir Med 2017 Volume 2 Issue 2
Objective:
To identify the incidence of and predictors for tuberculosis in children living
with HIV in Northern Ethiopia.
Design:
Observational, retrospective follow-up study.
Methods:
A total of 645 HIV-infected children were observed between September
2009 and September 2014. Cox regression analysis was used to identify predictors for
developing TB.
Results:
The incidence rate of tuberculosis was 4.2 per 100 child-years. Incidence
of tuberculosis was higher for subjects who were not on cotrimoxazole preventive
therapy, were not on isoniazid preventive therapy, had delayed motor development,
had a CD4 cell count below the threshold, had hemoglobin level less than 10 mg/dl and
were assessed as World Health Organization (WHO) clinical stage III or IV.
Conclusion:
Incidence of TB in children living with HIV was high. This study reaffirmed
that isoniazid preventive therapy is one of the best strategy to reduce incidence of TB
in children living with HIV. All children living with HIV should be screened for TB but for
children with delayed motor development, advanced WHO clinical stage, anemia or
immune suppression, intensified screening is highly recommended.
e:
yihun.mulugeta@yahoo.comHigh incidence of tuberculosis in the absence of isoniazid and cotrimoxazole preventive therapy in
children living with HIV in northern Ethiopia: Aretrospective follow-up study
Yihun Alemu
MPH- Epi-Bio., Ethiopia