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Journal of Clinical and Experimental Toxicology | Volume: 03 | ISSN: 2630-4570
November 04-05, 2019 | Prague, Czech Republic
2nd World Congress on
TOXICOLOGY AND APPLIED PHARMACOLOGY
Introduction: Diphoterine is an amphoteric, slightly
hypertonic, polyvalent, sterile water-based eye/skin
decontamination solution which combines passive flushing
with active chemical decontamination. Reviews were
published in French (Minaro et al, 2000) and Hall et al
(2002). Since that time, many more studies of Diphoterine
safety and efficacy, both pre-clinical and clinical, have
been performed. This review describes earlier studies and
details more current ones. Some of these were described in
reviews at the Medichem Conference, Basel, Switzerland,
2016, at the AMPAT Congress, Singapore, 2016, and the
AOHC Congress, Kaohsiung, Taiwan. Presented here are
new not previously presented data.
Materials and Methods: A review of all new data since
previous presentations was performed.
Results: Non-Clinical: In vitro/ex vivo comparative
decontamination studies with phenol (acid) and
tetraammonium hydroxide (TMAH) (base) have
been performed. In both cases, Diphoterine solution
decontamination was superior to water decontamination.
Clinical studies have included a 20-year chemically
exposed eye study from Germany in which Diphoterine
solution was found better than any other rinsing solution.
A multi-center, multinational clinical study from France
and Belgium showed the efficacy of Diphoterine solution
for decontamination of chemically exposed skin, eyes,
and oral membranes in the pre-hospital and emergency
department settings. Similar results were found in a clinical
study of occupational phenol exposure outcomes in Taiwan
and exposure to various various caustic substances in India.
Conclusion : Based on previously published/presented data
and data presented here, Diphoterine solution is a better
choice than potable water or other rinsing solutions for
first aid, pre-hospital, and emergency department (even if
delayed) decontamination of chemical eye/skin exposures.
Biography
Alan H Hall is a board-certified Medical Toxicologist at Toxicology
Consulting and Medical Translating Services, Azle and Springtown, Texas,
USA and Clinical Assistant Professor, Colorado School of Public Health,
University of Colorado-Denver, Denver, Colorado, USA.
Laurence Mathieu is a chemical engineer (ECM) and has a PhD in organic
chemistry and catalysis. She is the Head manager of “Scientific Action
Group” Department at PREVOR Laboratory.
e:
e:
Alan H Hall & Laurence Mathieu, J Clin Exp Tox, Volume: 03
DOI: 10.35841/2630-4570-C2-007
Laurence
Mathieu
Laboratoire Prevor, France
Alan H Hall
Colorado School of Public
Health, USA
Diphoterine solution decontamination of eye/skin chemical exposures: Review and
update on recent data