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Virology Research Journal | Volume 2
May 18-19, 2018 | Montreal, Canada
2
nd
World Conference on
STDs, STIs & HIV/AIDS
Background:
HPgV-2
is a novel blood-borne human pegivirus that
mainlyinfectshepatitisCvirus(HCV)andHuman Immunodeficiency
Virus type one (HIV-1) co-infected subjects. We have investigated
the prevalence of HPgV-2 in China, high risk population and its
association with HCV and HIV-1.
Methods:
A cross-sectional study was conducted with
both blood donors and HCV and HIV-1 infected patients in
Guangzhou, China. All subjects were screened for anti HPgV-2
and HPgV-2 RNA. Demographic and clinical information were
obtained from electronic medical records.
Results:
We tested 8198 serum or plasma samples. Only 0.15%
(6/4017) of healthy blood donors was positive for anti HPgV-2,
while negative for HPgV-2 RNA. No HPgV-2 viremiawas detected
in HBV or HIV-1 singly infected individuals. The relatively high
frequency of HPgV-2 infection was observed in 1.23% (30/2440)
and 0.29% (7/2440) of HCV-infected persons by serological
assay and RT-PCR, respectively. Furthermore, anti HPgV-2
and HPgV-2 RNA were detected in 8.91% (18/202) and 3.47%
(7/202) of HCV and HIV-1 co-infected subjects. The prevalence
of HPgV-2 in HCV and HIV-1 dually-infected people who inject
drugs (PWID) was 12.9% in Guangdong and 15.9% in Sichuan.
HCV/HIV-1-infected PWID represents a high-risk population for
HPgV-2 infection. HPgV-2 persistent infection was documented
in about 30% of anti HPgV-2 positive individuals.
Conclusion:
Our results indicate the rarity of HPgV-2 infection
in the general population and tight association with HCV, in
particular with HCV and HIV-1 co-infection. HPgV-2 appears
not to worsen HCV-related liver damage. Our study provides
new findings about the association of HPgV-2 and HCV/HIV-
1 and the impact of HPgV-2 infection on HCV replication and
pathogenesis.
Speaker Biography
Shixing Tang is a Professor at School of Public Health, Southern Medical University,
Guangzhou 510515, China.
e:
tamgshixing@smu.edu.cnShixing Tang
Southern Medical University, China
A novel human pegivirus HPgV-2 (HHpgV-1) is tightly associated with HCV/HIV-1 co-
infection