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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
I
nvolved in regulating many cellular processes, growth factors
signal proliferation and differentiation in cells throughout
the body. Growth factors such as VEGF and KGF have long
been known to play an important role in tissue regeneration.
The study of these cell-signaling processes has led to the
development of life-saving therapies and, more recently, the
role of growth factors in the aging process has been evaluated.
Histogen has developed a novel composition containing
naturally-secreted multipotent growth factors and soluble
matrix proteins which have been shown to stimulate both
mature cells and stem cells in the skin. The ability of this
growth factor composition, applied topically to facial skin, to
aid in the reversal of photodamage and other signs of aging
has been examined in multiple clinical studies. One study of a
formulation containing a high concentration of growth factors
resulted in statistically significant (p<0.02) improvement in
the appearance of skin brightness, firmness, and radiance at
day 14. Significant improvement in fine lines, pigmentation,
evenness and photodamage was seen at day 90.1 histogens
unique manufacturing process also results in upregulation of
growth factors, such as follistatin, which have been shown to be
important in hair viability and hair follicle stemcell proliferation.
A purified form of the multipotent growth factor composition
has been developed as an injectable for hair growth. Three
clinical trials of a hair stimulating complex (hsc) predecessor
have been completed, showing statistically and cosmetically
significant efficacy and excellent safety profile. Clinical data to
date supports the superiority of hsc against current treatments,
withhair growth appearing to remain two years after treatment,
temporal recession restoration, and effectiveness in men over
40 and in female patients. Naturally-secreted growth factors
represent an important new category in aesthetics, and have
been shown across clinical studies to stimulate skin and hair
follicle stem cells with anti-aging benefits.
Speaker Biography
Gail k Naughton has been in tissue engineering research for 30 years, holds over 105
patents, and founded two regenerative medicine companies. Her current venture,
histogen, is focused on novel products from hypoxia-induced stem cells. She is the
company’s CSO, CBDO and invented its core technology. She was the Founder/Co-
Inventor at advanced tissue sciences, where she oversaw the design and development
of the world’s first up-scaled manufacturing facility for tissue engineered products,
established major corporate development partnerships, and brought four products
from concept through market launch. At histogen, she developed a new skin care
product, regenica, which was recently acquired by allergan. She has been extensively
published and a frequent speaker in the field of tissue engineering. In 2000, she
received the 27th annual national inventor of the year award by the intellectual
property owners association in honor of her pioneering work in regenerative medicine.
e:
gnaughton@histogeninc.comGail K Naughton
Histogen Inc., USA
Naturally secreted growth factors for aesthetics: Stimulating skin and hair follicle stem
cells