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allied
academies
WORLD CONGRESS ON SMART MATERIALS AND STRUCTURES
&
3
rd
International Conference on
POLYMER CHEMISTRY AND MATERIALS ENGINEERING
November 21-22, 2019 | Singapore
Joint event on
Materials Science and Nanotechnology | Volume: 03
Drug delivery systems based on PCL nanoparticles obtained by non-aqueous emulsion
polymerization
Leonard Ionut Atanase
Apollonia University, Romania
C
ancer remains one of the world’s most devastating
diseases responsible for more than 20% of all deaths.
The conventional cancer treatments are generally
associated with a series of toxic side effects: cytotoxicity,
neurotoxicity, nephrotoxicity. In order to minimize these
drawbacks, the achievement of reliable and efficient
delivery systems of therapeutics, by the means of
nanotechnology, is highly recommended.
Drug delivery systems can play a key role in the fight
against cancers by delivering locally the anticancer
drugs, and the efficiency of this delivery depends
on several factors, such as: drug bioavailability, drug
absorption processes, pharmacokinetic processes, timing
for optimal drug delivery. The nanoparticles (NPs) are
based on biocompatible polymers and their advantages
are high drug encapsulation efficiency; improved drug
bioavailability; solubility and retention time; enhanced
chemical and biological stability; controlled drug release
rate; wide variety of administration routes.
New controlled drug delivery systems based on poly(Ɛ-
caprolactone) (PCL) biocompatible NPs were prepared
by a non-aqueous emulsion polymerization starting
from CL-in-PDMS non-aqueous emulsions stabilized with
tailor-made PDMS-b-PCL block copolymers. In this type of
emulsion, usually designated as oil-in-oil (o/o) emulsion,
the monomer droplets are dispersed in a non-miscible
oil and the stabilization can be achieved by using suitable
block copolymers. After the polymerization reaction, the
size of the obtained PCL particles, in the absence and in the
presence of a model drug, was determined by DLS.
e:
leonard.atanase@yahoo.com