psychiatry-2019-posters-abstracts

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May 20-21, 2019 | Rome, Italy

Journal Clinical Psychiatry and Cognitive Psychology | Volume 3

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Psychiatry 2019

PSYCHIATRY AND

PSYCHOLOGICAL DISORDERS

International Conference on

NEUROMELANIN´S INTRINSIC PROPERTY TO DISSOCIATE THE WATER MOLECULE, AS

CHLOROPHYLL IN PLANTS AND ITS IMPLICATIONS IN DEMENTIA AND PARKINSON´S

DISEASE

Arturo Solís Herrera

Human Photosynthesis Research Centre, México

rogressive degeneration of dopaminergic neurons in the zona compacta of the substantia nigra is character-

istic of neuro-degenerative diseases as Alzheimer´s disease, Parkinson´s disease and Huntington´s disease.

The causes remain unclear, it has been proposed increased level of nigral iron and secondarily major produc-

tion of hydroxyl radical, increased Mn superoxide dismutase activity; midbrain levels of reduced glutathione

diminished, increased oxidative damage in midbrain, including lipid peroxidation, protein oxidation and oxi-

dation of DNA; and finally, increased catechol oxidation in midbrain. Excessive oxidative stress in midbrain has

several deleterious outcomes in nigral neurons. It is remains unclear whether oxidative damage is restricted

to Substantia nigra neurons and the primary cellular targets of oxidative damage are a major consequence of

increased ROS production is inhibition of mitochondrial function. However, the unsuspected intrinsic property

of melanin to dissociate the water molecule as chlorophyll in plants opens a new panorama in the gloomy

environment of oxidative stress. This is melanin transforms light into chemical energy through dissociating the

water molecule, like plants thereby molecular hydrogen is produced, considered the best-known antioxidant

and the main energy carrier in the universe. The energy that the melanin requires to transform liquid water into

its gaseous components is captured from visible and invisible light; and the substrate for the process is abun-

dant, since the water molecule constitutes 70% of the body weight. It is to be expected that by normalizing the

function of neuro melanin, the available molecular hydrogen increases, which would substantially neutralize

the damage caused by elevated levels of oxygen radicals in patients with neurodegenerative diseases. The

unexpected bio-energetic role of neuromelanin breaks in thousand pieces the sacrosanct role of glucose as

source of energy of CNS, allowing new concepts about biology of neurodegenerative diseases as Alzheimer’s,

Parkinson and affective disorders.

J Clin Psychiatry Cog Psychol 2019, Volume 3