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Pharma Summit 2018 & Gastro Summit 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
GLOBAL PHARMA SUMMIT
GASTROENTEROLOGY AND HEPATOLOGY
2nd International Conference on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Fatma Abdelaziz Amer, Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C5-013
SURVEILLANCE AND IMPACT OF OCCULT
HEPATITIS B VIRUS, SEN VIRUS AND TT VIRUS
AMONG HEMODIALYSIS PATIENTS WITH
CHRONIC HEPATITIS C VIRUS INFECTION IN
THE EASTERN PROVINCE OF EGYPT
Egypt ranks the first as regards prevalence of hepatitis C virus infection.
Many patients have concomitant diseases like kidney disorders which ne-
cessitate hemodialysis, a procedure posing risk of transmitting other hepatitis
viral infections. Occult hepatitis B Infection (OBI) is blood- borne and Torque
teno virus (TTV) and SEN virus (mainly D and H genotypes) are tentatively
linked to non-A-E hepatitis. The purpose of this study is the surveillance of
OBI, SEN virus and TTV in chronic HCV (CHC) infected patients on mainte-
nance hemodialysis in Sharkya Governorate, Egypt and to identify their im-
pact. Three hundred and twenty- five patients were enrolled. They were divided
into two groups. Group 1 (case patients; 130 HCV RNA positive) and Group 2
(controls; 195 HCV RNA negative patients). All patients’ data were recorded.
Blood samples were collected before hemodialysis. Sera were tested for anti-
bodies to hepatitis B core (HBc) and surface antigens (HBs) using ELISA. HBV,
SEN virus-D and SEN virus-H and TTV DNAs were detected by polymerase
chain reaction. The serum activity of alanine and aspartate aminotransferase
were measured. Results were statistically analyzed. Positive anti-HBc anti-
bodies and HBV DNA were identified in 73.1% and 50.8% of group 1, versus
36.4% and 22.6% of group 2 patients respectively (statistically significant).
Significant elevation of aminotransferases was identified among group 1 than
group 2 patients. SEN virus was identified in 15 (11.5) of group 1; 6 SEN-D and
9 SEN-H versus 16 (8.2%) of group 2 patients; all were SEN-D. TTV was identi-
fied in 38 (29%) of group 1 versus 53 (27%) of group 2 patients. The existence
of neither SEN nor TTV had significant implications. Due to high occurrence
of OBI in our locality, diagnosis is recommended before hemodialysis for CHC
patients. No importance of SEN virus and TT viruses is identified.
Biography
Fatma Abdelaziz Amer graduated from the Faculty
of Medicine, Zagazig University, Egypt and got her
MSc and PhD degrees from the same university.
She is the past head of Medical Microbiology and
Immunology in Zagazig University, Egypt and the
past president of the Arab Alliance for the Prudent
Use of Antimicrobials. Currently she is an emeritus
professor in the same university, the president of
Hepatitis Working Group/International Society of
Chemotherapy and Infection and is a board mem-
ber of the International Society for Infectious Dis-
eases. She supervised and evaluated many MSc
and PhD theses, and is a reviewer of manuscripts
submitted for journals, conferences and interna-
tional awards. She published numerous articles.
She has been given many national, regional and in-
ternational awards. Through fund raising and provi-
sion of technical assistance she was the first to in-
troduce automated Microbiology Service in her uni-
versity and participated in the establishment of the
Molecular Biology Unit in the Medical Microbiology
and Immunology Department. She introduced an
MSc degree in Infection Control at her faculty. She
developed two volumes of Infection Control books;
the first of their kind in Egypt. She participated in
conferences all over the world as organizer, chair-
person and speaker.
Fatma Abdelaziz Amer
Zagazig University, Egypt