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Pharma Congress 2018 & Molecular Medicine 2018
& Psychiatric Disorders 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X| Volume 8
International Conference on
PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS
19th International Conference on
CELLULAR AND MOLECULAR MEDICINE
19th Annual Congress on
PSYCHIATRY AND PSYCHIATRIC DISORDERS
&
&
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Archakov A I, Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C3-007
MOLAR CONCENTRATION WELCOMES
AVOGADRO IN POSTGENOMIC ANALYSIS
T he researchers working with high-throughput methods of genomics, tran-
scriptomics, and proteomics reconsider the concept of concentration and
evaluate the data obtained in the number of copies of biomacromolecules.
Measurement of copy number reflects a steady trend in increasing the sensi-
tivity of postgenomic analytical methods, up to the level of a single molecule.
In this paper we review the physical meaning of the terms “molar concentra-
tion” and “Avogadro’s number” to establish a relationship between them. The
relationship between the molar concentration and the number of copies of that
same macromolecule in a certain volume is set through the reverse Avogadro’s
number, the value of which (≈10-24 М) characterizes the molar concentration
of a single molecule in one liter. Using the reverse Avogadro’s number, we deal
with situations in analyzing homogeneous biological solutions and heteroge-
neous cellular material.
Biography
Archakov A I Scientific Advisor of Institute of Bio-
medical Chemistry, was born January 10, 1940, in
Kashin, Kalinin (Tver) region – scientist, biochem-
ist.A.I. Archakov had organized a scientific school
to study molecular organization and functioning
of oxygenase cytochrome P450-containing sys-
tems, molecular mechanisms of the structure and
function of membranes and biological oxidation.
Under the guidance of A. I. Archakov, the institute’s
members have developed a fundamentally new
pharmaceutical composition “Phosphogliv” with
antiviral activity for the treatment of liver diseases
of various etiology. A.I. Archakov’s present-day/
current areas of expertise relate to research in the
field of post-genomic technologies, nanobiotech-
nologies, proteomics, development of approaches
to create personalized medicine of the future. A.I.
Archakov is the pioneer in the development of pro-
teomics in Russia. Currently, he is the international
“Human proteome” project coordinator in Russia/
the coordinator representing Russia in the interna-
tional “HP” project
Archakov A I
Institute of Biomedical Chemistry
Russian Federation