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Pharma Chem Congress 2019 Journal of Pharmaceutical Chemistry & Chemical Science | Volume 3
June 12-13, 2019 | Bangkok, Thailand
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
PHARMACEUTICAL
CHEMISTRY AND DRUG DISCOVERY
2nd International Conference on
THE HYPERTENSION RISK OF IRON BRAKES WITH RELEASE OF PARTICULATE MATTER
William J Rowe
University of Toledo, USA
Of 12 moon walkers, James Irwin on day after return from Apollo 15 mission, showed extraordinary bi-
cycle(B) stress test(ST) hypertension (275/125mmHg) after three minutes exercise, supervising >5000
maximum treadmill ST, author never witnessed ST blood pressure approaching this level. Symptom limited
maximum B stress test showed “cyanotic fingernails”, possibly venous blood trapped peripherally, supporting
author’s “Apollo 15 Space Syndrome”, postulating that severe fingertip pain during space walks, triggered by
plasma fluid, trapped distally; mechanism could be related to endothelial dysfunction, providing “Silent isch-
emia” warning. Neil Armstrong returned to Earth with severe diastolic hypertension (160/135 mmHg), consis-
tent with ischemic left ventricular dysfunction, 50mm increase in comparison with resting BP 110/85 mmHg.
With inhalation of lunar dust, brought into habitat on space suit with high lunar iron (I) this dust inhalation,
along with reduced(R) space flight transferrin, R antioxidant, calcium(Ca) blocker-magnesium, conducive to
severe oxidative stress, Ca overload with potential endothelial injuries. Using moon walker studies as example,
author’s recent editorials shows that iron dust, released from brakes, with over 90% of brakes made of iron, is a
major hypertension factor and may also contribute to myocardial infarctions.
William J Rowe, J Pharm Chem Chem Sci 2019, Volume 3
William J Rowe is a board certified specialist in Internal Medicine at Fellow British Interplanetary Society (FBIS), Fellow American
College of Nutrition, Retired Fellow Royal Society of Medicine (FACN). He received his MD at the University of Cincinnati and was in
private practice in Toledo, Ohio for 34 years. During that time he supervised over 5000 symptom -limited maximum hospital-based
treadmill stress tests. He studied three world class extraordinary endurance athletes and published their exercise-related magne-
sium deficiencies. This triggered a 20 year pursuit of the cardiovascular complications of space flight. He has published in LANCET
that extraordinary, unremitting endurance exercise can injure a perfectly normal heart. Of only four space syndromes, he has pub-
lished two: “The Apollo 15 Space Syndrome” and “Neil Armstrong Syndrome.”
BIOGRAPHY