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February 28-March 01, 2019 | Paris, France
Palliative Care, Obstetrics and Gynecology
Stroke and Clinical Trials
International Conference on
Joint Event on
International Conference on
&
Journal of Research and Reports in Gynecology and Obstetrics | Volume: 3
Role of vitamin D deficiency in female infertility and ART outcomes
Munazzah Rafique
King Fahad Medical City, Saudi Arabia
T
he prevalence of vitamin D deficiency in Saudi Arabia is
35%. In spite of adequate sunlight exposure 90 % cases
are due to dietary insufficiency. Vitamin D is an emerging
factor influencing female fertility and ART outcome. Hence
additional studies are pressingly needed to confirm a causal
relationship and to investigate the potential therapeutic
benefits of vitamin D supplementation.
Objective:
To assess the role of vitamin D deficiency and
perceive the outcomes of ART among vitamin D deficient
females in infertile females attending infertility clinic in
Riyadh Saudi Arabia.
Methodology:
A retrospective cohort study of all vitamin D
deficient infertile women who presented to Reproductive
Endocrinology and Infertility Department (REIMD), King Fahd
Medical City infertility center from January 2012 and January
2016 for a period of 4 yearswas performed. Randomsampling
was done to take around 192 infertile females who fulfill the
inclusion criteria for the study. The association of vitamin
D deficiency in infertile females between deficient and
insufficient groups was distinguished followed by analysis of
the outcome (aborted, ectopic pregnancy, molar pregnancy,
no pregnancy, successful pregnancy and unknown) after the
intervention done in the form of different ART options (OI,
IUI, IVF, ICSI). IRB approval was taken from the institutional
review board of King Fahad Medical City.
Results:
Among 192 patients in total, 56.2% had primary
infertility, 36.5% had an irregular menstrual cycle, 33.3% had
PCOS, 78.1% underwent IVF, and successful pregnancy was
observed in only 15.1%. Of the included women, 88.5% were
vitamin D deficient, (less than 50nmol/l) and 5.2% were
vitamin D insufficient (50-75nmol/l). In infertile women with
low vitamin D, there was also decrease in the level of FSH
and LH. When vitamin D deficient (<50nmol/l) and vitamin
D insufficient groups (50-75nmol/l) were compared the
maximum duration of infertility among vitamin D deficient
(29.4%), and vitamin D insufficient (40%) was six years.
Though vitamin D deficient patients had primary infertility
(57.6%), Vitamin D insufficient patients had secondary
infertility (50%). Almost 37.6% of vitamin D deficient and 30%
of vitamin D insufficient groups had an irregular menstrual
cycle. Most common ultrasound manifestation in vitamin
D deficient (33.5%) and vitamin D insufficient cases (40%)
was PCOS. 80.6% of vitamin D deficient patients underwent
IVF compared to 40% of vitamin D insufficient patients
with statistical significance less than 0.05 (p value=0.008).
Pregnancy with IVF was observed in 21.8% of vitamin D
deficient and 10% of vitamin D insufficient patients with
statistical significance less than 0.05 (p value=0.009). As for
the outcome, no pregnancy was observed in 62.3% vitamin
D deficient and 40% of vitamin D insufficient patients.
Successful pregnancy was confirmed in 15.3% of vitamin D
deficient and 20% in vitamin D insufficient cases.
Conclusion:
Both vitaminDdeficiency, aswell as insufficiency,
adversely affect the outcome of ART contributing to lower
pregnancy rates among Arabian women in the reproductive
age group. Vitamin D supplementation might bring on
treatment success in infertile patients undergoing IVF and is
recommended for infertile women in our region.
Speaker Biography
Munazzah Rafique is currently working as clinical research specialist in health information
standardization department at King Fahad Medical City. She has worked as physician
managing highly complex cases in King Fahad Medical City Riyadh with big patient
population and diverse problems in Obstetrics and Gynecology. She has worked as
dedicated Ob/Gyn Resident with accomplished background with sound knowledge in
the field of obstetrics and gynecology and worked with the team of professional which
enhancedherteachingskills.She isanactiveparticipantofresearchworkcurrentlyengaged
in research processes having visionary leadership stylewith the ability to inspire confidence
and creatively solve problems, remove obstacle and achieve breakthrough results.
e:
munazzahr@yahoo.comMunazzah Rafique
, Res Rep Gynaecol Obstet, Volume 3
DOI: 10.4066/2591-7366-C1-002