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Journal of Industrial and Environmental Chemistry| Volume: 3
February 18-19, 2019 | Paris, France
Joint Event
Green Chemistry and Technology
8th World Congress on International Conference on
Organic and Inorganic Chemistry
There is a need to develop sustainable and greener
processes in order to address excessive generation of
waste and recent advances in the field of biocatalysis is
making this possible. Biocatalysts in the form of enzymes
are environmentally-friendly, biodegradable, and adaptable,
enabling chemical transformations with remarkable regio-
and enantioselectivities. Protein engineering has enabled
the tailoring of enzymes to a required function and increased
catalytic efficiency, alter substrate recognition, and even
adding new structural functionality. The ability to implement
these engineered biocatalysts holds promise for sustainable
chemical manufacturing. However, several challenges remain
a barrier against a more widespread use of biocatalysis
including the cost of production of the biocatalyst itself
(difficulties in capturing and re-using the enzyme), as well
as the complexity of designing a manufacturing process. For
this, industry is looking at immobilisation as an opportunity.
Harnessing the synergy between biocatalysis and flow
chemistry, immobilisation onto a solid support makes it
possible to recycle the enzyme and, hence, reducing costs
associated with enzyme production. Immobilisation can
improve enzyme stability, prevent product contamination by
the enzyme reducing downstream processing requirements,
and facilitate the use of higher enzyme loadings for shorter
processing times. The EziG immobilisation platform is based
on polymer-coated controlled-porosity glass beads which
specifically anchor any protein containing a polyhistidine
(His6) tag. This platform offers a standardised solution
for targeted immobilisation of enzymes on a carrier.
These features of EziG enables biocatalysis to become an
accessible, effective, and sustainable choice for developing
greener processes.
Speaker Biography
Hans Jurgen Federsel is a PhD in Organic Chemistry, Royal Institute of Technology
(KTH), Stockholm (1980). Starting as process R&D chemist in Astra, Sodertalje, Sweden
(1974) he has occupied positions both as line and project manager. After the formation
of AstraZeneca (1999) he became Director of Science, followed by appointment as
Senior Principal Scientist. Academic qualifications led to an Associate Professorship
(KTH,1990) and a seat on the Board of the School of Chemical Science and Engineering.
In 2009 he was elected to the Royal Swedish Academy of Engineering Sciences.
After closure of the R&D unit in Sodertalje (2012), he relocated to Macclesfield, UK
maintaining his previous role. In 2017 (February) he returned to Sweden, picking
up a role as Chief Scientific Officer in EnginZyme – a biotech company developing
a technology platform in biocatalysis, aimed at immobilization of enzymes. Since
1st January 2019, he has taken on the position as Vice President Science Relations.
e:
Hans Jurgen Federsel
EnginZyme, Sweden
Future of biocatalysis – Enzymatic reactions in continuous flow processes
Hans Jurgen Federsel, J Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C1-007