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Journal of Intensive and Critical Care Nursing | Volume 2
May 23-24, 2019 | Vienna, Austria
Nursing Care
28
th
International Conference on
J Intensive Crit Care Nurs, Volume 2
H
ealth professionals chronically exposed to cytostatic
drugs, formaldehyde and anesthetic gases in
hospitals are at higher risk of lung diseases, hematological,
immunological and reproductive alterations. Without safety
devises, cytostatic and anesthetic gas exposure often exceeds
the safety limits, especially when no proper ventilation has
been installed in operating theaters. In the present study we
assessed the health risk among exposed nurses andmeasured
geno-toxicological parameters in the presence or absence of
confounding factors such as smoking. The investigations were
carried out in 800 subjects, exposed to different hazards using
in health services. The data were compared to healthy, non-
exposed controls. The measured biomarkers were clinical
laboratory routine tests, completed with geno-toxicological
(Chromosome Aberrations (CA) and Sister-Chromatid
Exchange (SCE), DNA repair) and immunotoxicity. The
exposed groups were divided into three main groups exposed
to cytostatic drugs, anesthetic gases and formaldehyde.
In the groups of health personnel exposed to cytostatic
and formaldehyde was carried out elevated chromosomal
aberrations and depressed DNA-repair. Although those
nurses who were exposed to anesthetic gases, we did not
find significant changes in the frequency of chromosome
aberrations. Sister-chromatid exchange rate in anesthetic
gas exposed smokers, was increased, when it was compared
to nonsmokers. We also found increases of apoptosis and
inhibition of UV induced DNA repair capacity. Clinically these
exposed individuals had high incidences of anemia, elevated
serum glucose levels, thyroid dysfunction and benign tumors
compared to controls. Low level of cytogenetic changes may
relate to the increased apoptotic rate of peripheral blood
lymphocytes and depressed DNA-repair capacity due to the
low risk of misrepair. Our results suggest that biomarkers can
be useful in tracking occupational/environmental genotoxic
effects among exposed health personnel.
Speaker Biography
Anna Tompa was graduated in medicine in Budapest Semmelweis Medical
University and became an Assistant Professor at the Institute of Pathology
and Cancer Research of the School of Medicine. After specialized
in pathology she went to the United States to study the advanced
methodology of experimental cancer research. She has continued her
research activities focused on the cancer prevention and obtained her
D.Sc.in 1999 from Hungarian Academy of Sciences. She has written more,
than 160 publications and given about 200 scientific lectures in different
domestic and international congresses. She is a member of numerous
domestic and international scientific societies, and presently she is
emeritus fellow of Ramazzini Collegium and OECD expert in chemical
safety. Today, She is an emeritus professor and vice director of Public
Health Institute in the Semmelweis University, Budapest, Hungary.
e:
tompa.anna@med.semmelweis-univ.huAnna Tompa
1
and
Anna Biro
2
1
Semmelweis University, Hungary
2
National Public Health Institute, Hungary
Hungarian nurse study for occupational cancer risk assessment
using Geno-Toxicological Methodology