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N o v e m b e r 2 1 - 2 2 , 2 0 1 8 | M a d r i d , S p a i n
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alliedacademies.comYEARS
Nephrology 2018
Journal of Clinical Nephrology and Therapeutics
|
Volume 2
NEPHROLOGY AND UROLOGY
International Conference on
Roman Aizman et al., J Clin Nephrol Ther 2018, Volume 2
EFFECT OF CALCIUM AND MAGNESIUM
HIGH CONTENT IN HARDNESS DRINKING
WATER ON KIDNEY FUNCTIONS
Roman Aizman, Svetlana Nedovesova
and
Eugene Trofimovich
Novosibirsk State Pedagogical University, Russia
T
he effects of prolonged consumption of hardness drinking water with in-
creased content of Mg
2+
and Ca
2+
on renal functions in rats were studied.
The experiments were performed on Wistar male rats of 3 groups: control (C)
(Ca
2+
-10 mg/L and Mg
2+
-5 mg/L), and experimental – E1 (Ca
2+
-120mg/L ) and
E2 (Mg
2+
-60mg/L). At the 1-st, 2-d, 4-th and 6-th months of water intake in
rats the urine and blood samples were collected before (background) and af-
ter a 5% water load. The concentrations of Na
+
, K
+
, Ca
2+
, Mg
2+
, urea, osmolality
and hormones (corticosterone, T3 and T4) were determined. It was shown
that both experimental groups an activation of osmoregulatory renal function
compared with the control have manifested, that was to reduce urine output
by increasing of fluid reabsorption, the osmolality of the urine, the excretion
of Ca
2+
and reducing potassium and magnesium excretion. The output of Na
+
,
urea practically did not differ between groups. Drinking water in group E2
caused more significant changes in renal function than water in group E1. Af-
ter the water loading differences in renal response between the groups were
not expressed, especially to the 6-th month, indicating a decrease in the level
of stress of the osmotic and ion - regulating mechanisms after hydration. The
concentration of the described ions in plasma did not differ between groups,
and the content of the main stress hormones (corticosterone, thyroxine, tri-
yiodothyronine) responsible for adaptive adjustment of the organism by the
end of the observation was significantly lower than in the group C, which is
likely to indicate a manifestation of a stress reaction to hardness drinking
water with its subsequent depletion. Thus, long-term intake of drinking water
with high content of Mg
2+
and Ca
2+
causes adaptive adjustment of hormonal
and renal responses, the value of which depends on the concentration of ions
in the water and the consumption time duration.
Roman Aizman has got his Doctor degree from Moscow
Research Institute of Developmental Physiology in 1985.
He is the head of the dept. of Human Anatomy, Physi-
ology and Life Safety, director of the Scientific Research
Institute of Health and Safety, professor of Novosibirsk
State Pedagogical University, Russia. He has over 700
publications that have been cited over 3900 times, and
his publication H-index is 26.
aizman.roman@yandex.ruBIOGRAPHY