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Biol Med Case Rep 2017 | Volume 1 Issue 2
allied
academies
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
N
anomedicine is poised to shape the sustainability
of industries and wealth of nations, and transform
economies and societies on a global scale. The global market
for nanomedicine was $250 billion in 2014 and it is expected
to reach $550 billion by 2020. Nanotechnology is the solution
to detection, diagnosis, and treatment of many diseases as
biological processes and cellular mechanisms work at the
nanoscale. Translation of nanoscale discoveries from the
laboratory to the market promises new diagnostic tools, drug
targeting systems, gene therapy platforms, biomaterials,
regenerative tissue constructs, and personalized medicine. A
major application of nanotechnology in medicine is in cancer
therapy. A major contributing factor to mortality in cancer
patients is relapse after therapy and developing resistance.
Cancer recurrence and resistance is related to the existence
of a very small population of initiating stem cells in the tumor
tissue. I will present strategies based on nanomaterials to
selectively target chemotherapeutic agents to the stem cell
sub-populationof cells in the tumor tissue. Another important
application of nanomedicine is in regeneration of skeletal
tissues. In the process of bone formation, osteogenesis and
vascularization are coupled by spatiotemporal regulation of
paracrine signaling in which the invading vascular endothelial
cells secrete osteogenic morphogens to stimulate cell
differentiation and bone formation. The stratified structure
of articular cartilage is rooted in the spatiotemporal gradients
of morphogens that direct the formation of morphologically
distinct cartilage zones. I will present nanoparticle-based
strategies for spatiotemporal release of morphogens for
coupling osteogenesis and vascularization and to stimulate
the formation of zonal architecture of articular cartilage.
Speaker Biography
Dr. Jabbari is a Tenured Full Professor of Chemical and Biomedical Engineering and
the Director of Biomaterials, Tissue Engineering and Drug Delivery at the University of
South Carolina. He earned his Ph.D. from Purdue University in Chemical Engineering.
He began his independent career as an Assistant Professor in the Departments of
Biomedical Engineering and Orthopedic Research at Mayo Clinic upon completion of
his post-doctoral training at Monsanto and Rice University. Jabbari’s research is focused
on engineering 3D multi-cellular co-culture systems and the effect of spatiotemporal
delivery of growth factors and physico-mechanical factors in the microenvironment
on function and fate of stem cells for applications in skeletal tissue regeneration
and cancer stem cell therapy. He received the Berton Rahn Award from the AO
Foundation in 2012 and the Stephen Milam Award from the Oral and Maxillofacial
Surgery Foundation in 2008. He was elected to the College of Fellows of the American
Institute for Medical and Biological Engineering (AIMBE) in 2013. He has published
>250 books, book chapters, refereed journal articles (107 peer-reviewed), and
conference proceedings, and presented >260 seminars at national and international
conferences (67 plenary, keynote, and invited seminars). He currently serves as the
Technical Chair as well as the Programming Chair for Bionanotechnology theme of the
annual conference of Engineering in Medicine & Biology Society (IEE-EMBS). He serves
as the Academic Editor for PLOS ONE, Editor of International Journal of Biomaterials,
and North America Editor of Journal of Biomaterials and Tissue Engineering. Dr. Jabbari
has mentored >130 visiting scholars, medical residents, post-doctoral scientists, and
engineering students. He is a member of numerous scientific organizations including
AIChE, BMES, ACS, EMBS, SFB, TERMIS, MRS, ACS, and AACR.
e:
jabbari@cec.sc.eduEsmaiel Jabbari
University of South Carolina, USA
Nanomaterials in regenerative medicine and cancer therapy