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Journal of Biomedical Research | Volume: 29
4th World Heart Congress
Molecular Biology, Tissue Science and Regenerative Medicine
International Conference on
Joint Event
&
November 19-20, 2018 | Paris, France
Angiogenesis is an important component in tumor
development, progression and spread. As a result, there
are ongoing efforts to combine existing cytotoxic therapy with
anti-angiogenic therapy to enhance the efficacy of cancer
treatment. However, the optimal scheduling of anti-angiogenic
therapy with cytotoxic therapy, although crucial for maximizing
treatment efficacy, remains unclear. The aim of this study is to
investigate VEGF regulation following cytotoxic therapy as a
basis for the efficacy of combination anti-angiogenic therapy.
Materials and methods: Orthotopic prostate tumors were
implanted in the prostate of 6-week-old male severe combined
immunodeficient mice. In particular, we investigated the
effect of the combination treatment strategy on the two
major patterns of metastasis: Hematogenous as well as
lymphatic metastasis. Here, we investigated an optimal
protocol for combining avastin anti-angiogenic therapy with
photodynamic therapy (PDT), a cytotoxic therapy for various
diseases including cancer. We demonstrate that PDT leads
to a temporally-transient regulation of vascular endothelial
growth factor (VEGF) following treatment. More importantly,
combination avastin therapy was most effective in inhibiting
lung metastasis when delivered around the peak of VEGF
response following PDT. Considering that temporally transient
VEGF regulation was observed following PDT, radiotherapy
and chemotherapy. In conclusion, optimal scheduling of
combination of anti-angiogenic therapy based on temporal
dynamics of the VEGF response has effective control of the
local tumor as well as distant metastasis in cancer prostate.
Speaker Biography
Mohamed Abd Ellatif completed his studies at Mansoura University (1985-1995) and
Toronto University (2001). Then he went back to Mansoura University and joined as
a professor in Medical Biochemistry and Molecular Biology, Faculty of Medicine. In
2007, he joined as a professor of Clinical Biochemistry and Molecular Biology, College
of Medicine, King Khalid University, Kingdom of Saudi Arabia during the period from
2/9/2007 till now. He has more than 55 research papers in national and international
journals. He attended more than 43 international and national workshops and
conferences. He is an active reviewer for many scientific journals and conferences. He
handled 8 master thesis and 7 PhD thesis.
e:
Mohamed Abd Ellatif
King Khalid University, Saudi Arabia
Optimal scheduling of combination PDT with anti-angiogenic therapy for effective
control of local prostatic tumor and distant metastasis
Mohamed Abd Ellatif, Molecular Biology & Heart Congress 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C8-021