materials-chemistry-2018-keynote

2 / 6

Page 8
Notes:
allied
academies
Journal of Materials Science and Nanotechnology | Volume: 2
August 20-21, 2018 | Paris, France
Materials Science and Materials Chemistry
International Conference on
Advanced multi-functional ceramics, like nano
hydroxyapatites containing Mg, Zn, Sr and Si within
hydroxyapatite (HAP) lattice, noted HAP-Mg-Zn-Sr-Si, are of
a major interest for hard tissue engineering and biomedical
applications, particularly due to their similarity with biological
HAP from bone structure. Among the innovative strategies,
the ionic substitution represents an intelligent tool to improve
the biological efficiency of nanobiomaterials based on HAP, as
a new generation of advanced bioceramics based on multi-
substituted hydroxyapatites, ms-HAPs. Series of these advanced
ceramics were synthesized in our Physical Chemistry Center
by innovative strategies, including wet chemical precipitation
method, without surfactants or template molecules, by
thermal processing, lyophilisation and calcination. Thus, nano
ms-HAPs, containing divalent cations of Mg, Zn and Sr, as well
as with Si as orthosilicate, were synthesized and thoroughly
characterized. Particle size, crystallinity, morphology, specific
surface area of obtained advancedmulti-functional bioceramics
were investigated by XRD, ICP-OES, SEM-EDX, FT-IR and FT-
Raman spectra, HR-TEM, AFM and BET measurements. The
obtained data confirmed a unique nanostructured phase of the
highest compositional purity for all synthesized biomaterials.
Results also showed a distinct change in shape and size of
nanoparticles, and in crystallinity of lyophilized powders, non-
calcined or calcined, with ionic substitutions. The substitution
effect on biological performance of these bioceramics
was investigated on primary human osteoblasts in culture
media. Therefore, innovative scaffolds were fabricated by
supramolecular engineering approach from advanced HAP-Mg-
Zn-Si and HAP-Mg-Zn-Sr-Si bioceramics self-assembled alone or
with collagen: COL on solid/liquid interface. Human osteoblasts
response on doped HAPs was assessed by viability tests, like
MTT assay, adhesion and proliferation, and protein expression
for osteoblast markers, such as collagen type 1, osteopontin,
osteonectin and osteocalcin. Moreover, the investigation of
alkaline phosphatase activity and F-actin stress fibers indicated
the highest biological performance for advanced functional
bioceramics compared with pure HAP scaffolds, particularly
in promoting the formation of mineralized bone matrix.
The enhanced biological performance of these advanced
nanomaterials recommends them for medical applications, as
bioactive coatings for smart orthopaedic and dental implants
and as bone substitute for bone repair and regeneration.
Certainly, these results demonstrate benefits of turning these
discoveries into health, withmultiple uses in clinical applications
for bone tissue repair and regeneration as well as in the
treatment of osteoporotic bone fractures. Consequently, multi-
substituted hydroxyapatites can be a promisingmulti-functional
bioceramic platform for nanomedicine applications.
Speaker Biography
Maria Tomoaia-Cotisel completed Ph.D. at the Babes-Bolyai University of Cluj-
Napoca, Romania, and postdoctoral studies from London University, King’s College,
UK. She is a corresponding member of the Academy of Romanian Scientists. She
was the visiting scientist at Philipps University of Marburg, (1989/1990), Germany,
State University of New York at Buffalo (1990/1991), US, National Institutes of
Health, (1991-1993) and Molecular/Structural Biotech., Inc., (1994-1997), Bethesda,
MD, USA. She is the founder and director of Research Center in Physical Chemistry
(2007- ) at BBU, STAR research institute. She published over 250 original research
papers, 5 patents, and 10 books in physical chemistry, including thermodynamics,
chemical structure, biophysics, bionanomaterials, colloids, and interfaces. She got
important awards, e.g., Gheorghe Spacu Award (1983, from the Academy in Romania),
Alexander von Humboldt Award (1986, Germany), Japan Society for Promotion of
Science and Technology Award (1986, Japan) and Fogarty Award (1991, USA) for
science and technology. She is a leader and supervisor for Ph. D. students in Doctoral
School of Chemistry at BBU, in physical chemistry, biophysics and material science.
e:
Maria Tomoaia-Cotisel
Babes-Bolyai University of Cluj-Napoca, Romania
Advanced nanostructured materials: Turning scientific discoveries into health