magnetic-materials-2018-posters-abstracts

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S e p t e m b e r 2 4 - 2 6 , 2 0 1 8 | B u d a p e s t , H u n g a r y

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Magnetic Materials 2018

Materials Science and Nanotechnology

Volume 2

MAGNETISM AND

MAGNETIC MATERIALS

International Conference on

Mater Sci Nanotechnol 2018, Volume 2

LABEL-FREE RAPID SILICON NANOTECHNOLOGY STRATEGY FOR SERS

DETECTION OF GLYCANS ON LIVE CELLS

Aisha Bibi

1,2

and

Yao He

1,2

Institute of Functional Nano and Soft Materials, China

Collaborative Innovation Center of Suzhou Nano Science and Technology, China

asically, glycan beautifies all mammalian cell surfaces through glycosylation. Glycan is one of the most important post-

modi cations of proteins. Glycans on cell surfaces facilitate a wide variety of biological processes, including cell growth and

differentiation, cell-cell communication, immune response, intracellular signaling events and host-pathogen interactions. High-

performance optical sensors are very important for rapid, sensitive and precise detection of chemical and biological species

for various fields, including biomedical diagnosis, drug screening, food safety, environmental protection etc. To explore the

novel kinds of sensors with low cost, portability, enough sensitivity, high specificity, excellent reproducibility, and multiplexing

detection capability remain in high demand. Therefore, a significant advancement of silicon nanotechnology, functional silicon

nanomaterials/nanohybrids (e.g., fluorescent silicon nanoparticles, gold/silver nanoparticles-decorated silicon nanowires or

silicon wafer, etc) featuring unique optical properties have been intensively employed for the design of high-quality fluorescent

and surface-enhanced Raman scattering (SERS) biosensors. Therefore, currently exists increasing concerns on the development

of a kind of high-performance SERS platform, which is suitable for glycan expression of different cell lines and as well as used

for the sensitive detection of glycans on live cells. Herein, we introduce the possibility of silicon-based probe for biomolecules

of interest near cells using SERS.