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Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
F
ibrolamellar hepatocellular carcinoma is generally a
fairly rare event in routine pathology practice. It is a
unique type of hepatocellular carcinoma with a distinctive
predilection for young patients without underlying liver
disease unlike most hepatocellular carcinomas which arise in
the background of liver injury such as hepatitis or cirrhosis.
It has a characteristic cell type composed of large polygonal
hepatocytes with eosinophilic and granular cytoplasm
surrounded by abundant, thick fibrous tissue arranged in
lamellar bands of collagen fibers, co-expression of cytokeratin
7 and CD68 and activation of protein kinase A (most often
by formation of DNAJB1-PRKACA). In this talk, the distinctive
clinic-pathologic features of Fibrolamellar hepatocellular
carcinoma and the diagnostic pathologic criteria will be
reviewed in detail. Further, updated molecular genetics and
associated signaling transduction pathway involved with this
specific tumor will be particularly highlighted as a primer for
anatomic pathologists.
Speaker Biography
Yue Xue has completed her MD/PhD training, followed by Anatomic and Clinical
Pathology residency at Dartmouth-Hitchcock Medical Center. She later did two
fellowships, one in Oncologic Surgical Pathology at Memorial Sloan-Kettering Cancer
Center, and the other on Gastrointestinal/Liver Pathology at Emory University. She is
an Assistant Professor at Emory University, where the liver transplant program was
ranked second nationally in 2017. As a Junior Faculty, she has published almost 20
original observations and written three book chapters, and been actively involving in
pancreatobiliary/liver research.
e:
yxue28@emory.eduFibrolamellar-type hepatocellular carcinoma: A histologically unique tumor with a distinctive
molecular alteration
Yue Xue
Emory University Hospital, USA