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Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
A
novel genus of specialized pro-resolving mediators
(SPMs) has been discovered to be involved in the active
clearance and regulation of inflammatory exudates to restore
tissue homeostasis. One of the lipid mediators, resolvins
(Rvs), are formed via specific transcellular biosynthetic
pathways at strict temporal intervals during the inflammatory
response. While accumulating evidences suggest RvD1
counteracts proinflammatory signaling and promotes
resolution, the specific cellular targets and modes of action
for RvD1 remains largely unknown. Ischemia/reperfusion
(IR) injury is an unavoidable sequela of major liver surgery
and is characterized by a sterile inflammatory response
jeopardizing the organ. We have recently reported that RvD1
facilitates M2 macrophage polarization of Kupffer cells and
efferocytosis via ALX/FPR2 signaling in the animal model
of liver IR. Moreover, our most recent
in vivo
and
in vitro
findings have implied that a crosstalk between mitochondrial
oxidative stress and RvD1 is pivotal in the protection of IR-
induced hepatocellular damage (
unpublished data
), which
give us a clue for solving the conundrum of cellular and
molecular mechanisms of liver IR injury. Our study justifies
that RvD1 might be a useful pharmacological maneuver for
attenuating liver sterile inflammation such as IR injury.
Speaker Biography
Jung-Woo Kang has completed his Ph.D in 2015 from School of Pharmacy,
Sungkyunkwan University. Dr. Kang has currently been a postdoctoral associate in
Department of Internal Medicine, Section of Digestive Diseases, Yale University. Dr.
Kang have performed a number of studies investigating signaling pathways in clinically-
relevant hepatotoxicity models and applying novel pharmacological strategies. Dr. Kang
has published more than 20 papers in the journals of pharmacology and biochemistry.
e:
jungwoo.kang@yale.eduTherapeutic potential of resolvin D1 in the treatment of liver sterile inflammatory diseases
Jung-Woo Kang
1,2
, Hyo-Sun Choi
1
, Jun-Kyu Shin
1
and
Sun-Mee Lee
1
1
Sungkyunkwan University, Republic of Korea
2
Yale University School of Medicine, USA