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Infectious Diseases Congress 2019

Journal of Bacteriology and Infectious Diseases | Volume 3

June 12-13, 2019 | Bangkok, Thailand

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

BACTERIOLOGY AND INFECTIOUS DISEASES

Global Congress on

COMPUTATIONAL IDENTIFICATION OF NOVEL INHIBITORS AGAINST

KLEBSIELLA

PNEUMONIAE

DNA ADENINE METHYLTRANSFERASE

Umairah Natasya Mohd Omeershffudin, Nurul Azira Bt Ismail

and

Suresh Kumar

Management and Science University, Malaysia

lebsiella pneumoniae

a gram-negative bacteria causing pneumonia, urinary tract infection and liver abscess

infections in the nosocomial settings. These bacterial pathogens are classified under the urgent hazard level

leading towards a concern in public health. The epidemiology remains enigmatic and the current antibiotics

failing to combat the emerging antimicrobial resistant bacteria. DNA methylation is seen to play a vital role

in regulating the gene expression, directed mismatched repair and are seen to influence the bacterial patho-

genicity. Current antibiotic-resistant studies have been progressively associated with DNA adenine methyl-

transferase (DAM) inhibitors, which play a crucial role in bacterial pathogenesis. Author’s aim of the study is to

screen novel natural inhibitor for

Klebsiella pneumonia

DNA adenine methyltransferase. They had performed

fingerprint similarity search based on Mahanine which resulted in 22 similar structures. Based on virtual screen-

ing using Autodock and ADMET test, they identified Koenimbine having a high affinity towards our previously

identified protein target (A0A2U0NNR3) with -5.67kcal/mol and does not violates the Lipinski Rule of 5. This

study will provide insight towards the identification of the new natural bioactive compound as a potential drug

target to combat antimicrobial resistant pathogens.

Umairah Natasya Mohd Omeershffudin et al., J Bacteriol Infec Dis 2019, Volume 3

Umairah Natasya Mohd Omeershffudin is an undergraduate student fromManagement and Science University, Malaysia. Currently

she is doing her final year Bachelor in Bioinformatics (Hons). Her research focusing on finding novel drug target for antimicrobial

resistant bacterial pathogens using computational aided drug design.

BIOGRAPHY