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Virology Research Journal
|
Volume 2
Page 47
allied
academies
IMMUNOLOGY AND CELL BIOLOGY
BACTERIOLOGY AND INFECTIOUS DISEASES
&
Global Summit on
Global Congress on
J u n e 2 5 - 2 6 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Joint Event on
FIFTY SHADES OF STRESS: A COLOURFUL SCREENING
PLATFORM FOR DETECTING BACTERIAL CELL STRESS
Laurens Ter Haar
Leiden University, Netherlands
A
ntimicrobial resistance poses a serious threat to global public health. The number of drug-resistant pathogenic bacterial
strains is rising at an alarming rate, while only a handful of new marketable antibiotics have been introduced in the past
three decades. Current drug discovery efforts suffer from tunnel vision: screening is limited to lethal compounds. This method
overlooks a goldmine of compounds that do not directly kill the bacterial cell, but do induce stress. iGEM Leiden aims to develop
an innovative screening platform, enabling rapid discovery of compounds which stress bacterial cells: Fifty Shades of Stress.
This will allow high-throughput screening of compound libraries, which ultimately can be utilized to establish novel combination
therapies. Fifty Shades of Stress will thereby help safeguard humanity against multi-drug resistant disease outbreaks.
igem@science.leidenuniv.nlVirol Res J 2018, Volume 2