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Notes:
3
rd
International Conference on
Health Care and
Health Management
Joint Event
&
November 04-05, 2019 | Prague, Czech Republic
6
th
International Conference on
Neuroscience and
Neurological Disorders
Journal of Public Health Policy and Planning | Volume 3
Microelectrode recording and deep brain stimulation
Amal Mokeem
King Faisal Specialist Hospital & Research center, KSA
Introduction:
Microelectrode recording (MER) Defined as
Neurophysiological Technique that detect and amplifies the
activity of Individual Single Neural Units.
Mechanism of Deep Brain Stimulation (DBS):
• HFS suppresses the activity of STN, STN neurons
discharge spontaneously at a frequency of ~ 20 Hz.
• PD they became hyperactive with an average firing ~
40Hz.
• DBS HFS at >100Hz, STN will increase firing during the
initial stimulation period after which they will fail to
respond secondary to inactivation of Na
+
channels,
result in synaptic inhibition.
• This stimulation induced activation of inhibitory
presynaptic terminals result reduction of pathologic
activity and its transmission, and subsequent
improvement in information processing high likely
responsible for amelioration of motor symptoms during
DBS
The Food and Drug Administration (FDA) approved DBS as a
treatment for:
• Essential tremor in 1999
• Parkinson's disease in 2002
• Dystonia in 2003
Methods:
Ptients slection criteria is important. A number of
stimulation techniques may be performed during movement
disorder surgery.Used either:
• To asses’ side effect (proximity to structures wish to
avoid)
• To assess the potential clinical effect of chronic
stimulation.
Conclusion:
Deep Brain Stimulation (DBS) is safe procedure.
It is safety Greatly depend on:
• The quality of the instruments.
• The method of stereotactic planning.
• The experience of the surgical and neurophysiology
team.
Complication of Deep Brain Stimulation (DBS) could be
Numbness, tingling, Symptomatic subdural hemorrhages,
Infection, Hardware issues.
Speaker Biography
Amal Mokeem is a Consultant Clinical Neurophysiologist at King Faisal
Specialist Hospital and Research Centre, Saudi Arabia. She has been in the
Arab Board – Dec 2003 and Saudi Board – Feb 2004. She has done Pediatric
Neurology Fellowship at King Faisal Specialist Hospital & Research Centre,
Riyadh, Saudi Arabia during 2004-2006, at British Columbia’s Children’s
Hospital, Canada during 2006-2007, Clinical Neurophysiology EEG
Fellowship at British Columbia’s Children’s Hospital, Canada during 2007-
2008, Clinical Neurophysiology Intraoperative NeurophysiologyMonitoring
(IOM) Fellowship at Vancouver General Hospital, Canada (2008-2009) and
Neurophysiology and Deep Brain Stimulation Fellowship at Lahey Clinic/
Tufts University, USA (2009-2010). She is having 2 Publications and gave
more than 10 International Presentations.
e:
aamokeem@gmail.com