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S e p t e m b e r 0 6 - 0 7 , 2 0 1 8 | B a n g k o k , T h a i l a n d

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Joint Event on

Global Women Health 2018 & Orthopedics Congress 2018

Archives of General Internal Medicine

ISSN: 2591-7951

Volume 2

BREAST CANCER, GYNECOLOGY AND WOMEN HEALTH

ORTHOPEDICS AND RHEUMATOLOGY

World Congress on

Annual Conference on

Tahir M Afzal, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C3-008

ANKYLOSING SPONDYLITIS AND

QUANTIFYING HLA B27 IN THE DIAGNOSIS

Tahir M Afzal

Government Medical College of Jammu, India

nkylosing spondylitis is a chronic inflammatory sero-negative spondy-

loarthropathy. AS occurs 0.1 to 0.2% in general population. Genetic and

environmental causes have been attributed AS causative influences. AS is

believed to have an autosomal dominant inheritance. HLA B27 positivity is

seen in 81-96% of patients. Axial skeleton is predominantly involved. Basic

pathological change in AS is enthesopathy or enthesitis which results in os-

sification at places of insertion of tendons and ligaments eventually leading

to ankylosis. Predominantly young males involved with male female ratio of

3:1 and usual age of onset is 20-30 years There are no specific lab tests for

daignosis of AS. ESR, CRP, serum IgA and ALP are usually elevated. Rheuma-

toid factor/anti-CCP/ANA are not associated with the disease. It is important

to diagnose the disease early in the course to prevent the development of irre-

versible deformity. Non-steroidal drugs are mainstay of the treatment. Physi-

cal therapy is of paramount importance in the total management to minimize

degree of deformity and disability.

Tahir MAfzal is a MBBS, MS, Trauma and Arthroscopy

Surgeon and an Assistant professor at GMC Jammu,

India. He has done his post graduate diploma course

in rheumatology.

BIOGRAPHY