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S e p t e m b e r 0 6 - 0 7 , 2 0 1 8 | B a n g k o k , T h a i l a n d
Global Women Health 2018 & Orthopedics Congress 2018
Note:
Page 31
allied
academies
BREAST CANCER, GYNECOLOGY AND WOMEN HEALTH
ORTHOPEDICS AND RHEUMATOLOGY
&
World Congress on
Annual Conference on
Joint Event on
Archives of General Internal Medicine
|
ISSN: 2591-7951
|
Volume 2
Arup Ratan Bandyopadhyay, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C3-007
HAPTOGLOBIN AND HEMOLYTIC DISEASE
OF THE NEWBORN: A STUDY ON BANGALEE
HINDU CASTE POPULATION, WEST BENGAL,
INDIA
H
emolytic disease of the newborn (HDN) used to be a major cause of
fetal loss and death among newborn babies. It has been recognized that
maternal-fetal ABO incompatibility is the most frequent cause of HDN. The
present study attempts to find the role of haptoglobin in the hemolytic disease
of the newborn (HDN), to ascertain the selective advantage of HP*1 alleles over
HP*2 alleles, and to find the association of haptoglobin with ABO blood group
system. To achieve the purpose a total of 572 children with HDN were studied
along with their parents. On the other hand, 1000 newborns without HDN
as controls were taken as controls. ABO blood group was done by antigen-
antisera agglutination test and haptoglobin (HP) types were ascertained by
Polyacrylamide Gel Electrophoresis (PAGE) following standard techniques.
Allele frequencies of these polymorphic markers calculated were computed by
maximum likelihood estimation. Distribution of haptoglobin groups according
to ABO blood group mother–child combinations were studied. Mothers of HDN
patients revealed an excess frequency of `O` alleles and children with HDN
demonstrated a significant excess of ‘A’ alleles compared to those of control
1000 newborns. The allele frequency of HP*1, was found to be higher among
HDN children with ABO incompatible mother-child combinations, than those
among the HDN patients with ABO compatible mother-child combinations.
Further follow up of the HDN samples without detectable haptoglobin types
required exchange transfusion, but those with detectable haptoglobin types did
not require exchange transfusion irrespective of mother–child combination.
Trend towards protective effects of HP in mean hemoglobin level and other
parameters of HDN patients was evident.
Biography
Arup Ratan Bandyopadhyay is Professor and for-
mer Head of the Department of Anthropology, Uni-
versity of Calcutta. He did MPhil and PhD from Uni-
versity of Calcutta, India. He is the recipient of UGC
Research Fellowship (for pursuing PhD, qualifying
National Eligibility Test), merit award and Young
Scientist award. He was President of Anthropo-
logical and Behavioral Sciences section of the In-
dian Science Congress in its centenary year. He re-
ceived seven national extra-mural research grants
as Principal Investigator, including a grant from the
British Council for collaboration with the Roslin In-
stitute, University of Edinburgh, UK. He published
more than 100 anthropological research articles in
national and international journals on evolutionary
biology, forensic anthropology, dental anthropol-
ogy, public health in relation to medical genetics,
cytogenetic and anthropometry of non-communi-
cable disease, dermatoglyphic in medical and psy-
chiatric disorders, and population genetics and hu-
man rights issues. He has delivered many invited
lectures and recently in International Conference in
Gynecology, Obstetrics and Reproductive Medicine
(GORM2018).
abanthro@caluniv.ac.inArup Ratan Bandyopadhyay
University of Calcutta, India