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D e c e m b e r 1 2 - 1 3 , 2 0 1 8 | A b u D h a b i , U A E
Journal of RNA and Genomics| Volume 14 General Pediatrics Congress 2018 Current Pediatric Research | ISSN: 0971-9032 | Volume 22
GENERAL PEDIATRICS, ADOLESCENT
MEDICINE AND NEONATOLOGY CONGRESS
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Subhasree Ray, Curr Pediatr Res 2018, Volume 22 | DOI: 10.4066/0971-9032-C3-008
EFFECT OF PROBIOTIC FOOD
SUPPLEMENTATION IN ENHANCING CD4
CELL PROFILE AND MALNOURISHED
STATUS OF HIV INFECTED ADOLESCENT
CHILDREN IN A SLUM OF MUMBAI
Subhasree Ray
Reliance Industries Limited, India
Human Immunodeficiency Virus (HIV) infection results in gastro-intestinal
damage, microbial translocation and immune activation which are as-
sociated with decreasing CD4 cell count and persistent abdominal distress.
The disease also leads to malnourished conditions like stunting, wasting and
growth retardation especially in adolescent population. According to sever-
al research studies, probiotic food supplementation has been demonstrated
promising result in improving CD4 cell profile and health status in children
living with HIV. The current observational prospective study has included 20
malnourished adolescent children (12 boys and 8 girls), aged from 14-16
years, who were supplemented with a local probiotic yogurt (Lactobacillus
bifidus) every day for 6 months along with their regular diet at a social service
centre of a slum in Mumbai city, India. CD4 cell profile, height, weight and
BMI were recorded and compared at the baseline and at the 6th month. The
children were on regular Antiretroviral (ARV) medication. The result revealed
an increase of 0.22 cells/μL/day (95% CI; 0.10-0.46, P=0.003) in 15 children
and 0.28 cells/μL/day (95% CI; 0.17-0.38, P=<0.001) in 5 children respective-
ly. The weight has been increased by 68% in 11 children and by 65% in 9 chil-
dren respectively. The height has been increased by 51% in 13 children and
by 53% in 7 children respectively. There was no case of drop out during the
intervention. The study has shown that the probiotic yogurt supplementation
is significantly associated with enhanced CD4 cell profile and malnourished
status of the adolescent children living with HIV. The study encourages inclu-
sion of probiotic foods in the daily diet of the adolescent children living with
HIV to prevent malnutrition, promote growth and boost immunity by enhanc-
ing CD4 cell profile.
Subhasree Ray is a final year PhD scholar from the de-
partment of Food Science & Nutrition, SNDT Women’s
University, Mumbai, India. She is currently working as the
Corporate Dietitian of Reliance Industries Limited and
heading the Nutrition department of the company. She
is a lifetime member of Probiotic Association of India,
Indian Dietitic Association and Nutrition Society of India.
Her research areas include ketogenic diet therapy, dietary
management of neurodegenerative diseases, medical
nutrition therapy, public health nutrition, food chemis-
try, probiotics, food toxicology, corporate wellness, food
toxicology, paediatric nutrition and nutrigenomics. She
has published 16 research articles so far in National and
International journals. She has presented 12 research
papers in various conferences worldwide as a young
researcher. She is working as a clinical nutritionist since
2010 and worked with UNICEF and national government
in managing severe acute malnutrition in remote villages
of India. She has also worked as an advisor for several
organizations in developing their nutrition policies.
BIOGRAPHY