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J u n e 2 8 - 2 9 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Joint Event on
OBESITY AND WEIGHT MANAGEMENT
VACCINES AND IMMUNOLOGY
&
International Conference on
International Conference on
Asian Journal of Biomedical and Pharmaceutical Sciences
|
Volume 8
ISSN:
2249-622X
Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C1-003
PHYSICAL ACTIVITY FOR METABOLIC EFFECTS IN OVERWEIGHT
AND OBESITY
Atiq Hassan
University of Maryland School of Medicine, US
O
verweight and obesity increase with aging and successful weight maintenance is difficult. Lifestyle rehabilitation changes
such as physical activity and nutritional therapies are advocated for the treatment of obesity and chronic diseases, and our
research suggests that these treatments are beneficial, in part, due to their metabolic and tissue effects. We have identified
some of the mechanisms in skeletal muscle by which these and other effective therapies reduce insulin resistance and improve
mitochondrial function thereby enhancing metabolic flexibility in aging. Our data indicate that older overweight individuals
with impaired glucose tolerance are metabolically inefficient, with the inability to switch from fat to carbohydrate utilization in
response to exercise and insulin. We also report that insulin activation of skeletal muscle glycogen synthase increases after
calorie restriction and exercise training in impaired glucose tolerant older adults. Furthermore, exercise training can enhance
activity of key skeletal muscle enzymes involved in lipid partitioning and fatty acid metabolism in older adults. We have examined
body composition and metabolic changes during a follow-up after intentional weight loss in older women. Multiple factors are
associated with the ability to sustain weight loss over a long period of time with predictors of weight regain in older women. There
is evidence that the addition of aerobic exercise training to weight loss is critical to altering the metabolic components of skeletal
muscle for advancement of healthy aging and are important in overweight and obesity.
aryan@som.umaryland.edu