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Cecilia Videnros, Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C7-020
OCCUPATIONAL EXPOSURE TO CHEMICALS
AND BREAST CANCER
Cecilia Videnros
Karolinska Institutet, Sweden
B
reast cancer is the most common cancer among women and accounts for
12% of all incident cancer cases worldwide, and 25% of all cancer cases
among women. Our previous study indicated differences in breast cancer risk
between occupational groups that could only partially be explained by the
known risk factors. Occupational chemical exposure have been linked to the
development of some cancer types, however breast cancer have been less
studied and the results are more ambiguous which is why more research on
this issue is necessary.
The aim of this study was to determine if chemical exposures in the work-
place are associated with increased risk of postmenopausal breast cancer.
Methods:
The study population comprised women born 1923-1950 who lived
in Malmö city, Sweden between 1991 and 1996, which resulted in 14, 119
women being included in the cohort study. Exposure data was assessed us-
ing the job-exposure matrices NOCCA and FINJEM, and applying the data to
the participants’ three latest occupations. An extensive set of individual data
on hormonal risk factors were collected via questionnaires at baseline and
used as confounding control. First time diagnoses of invasive breast cancer
were identified through the Swedish Cancer Registry until end of follow-up
2013-12-31. Women exposed to chemical exposure in their occupational
environment had a statistically significant increased risk (HR 1.26, 95% CI
1.02-1.54) of breast cancer compared to women who were not exposed. Spe-
cifically women exposed to diesel engine exhaust for longer than 10 year had
a statistically significant increased risk (HR 1.69, 95% CI 1.01-2.82) of breast
cancer. Measurements of cumulative exposure do not show an increased risk
of breast cancer; however duration of chemical exposure seemed to have a
negative effect on the breast cancer risk. Occupational chemical exposures
are attributed for 2% of the breast cancer cases in this population. Occupa-
tional chemical exposure seems to increase the risk of breast cancer among
women exposed compared to women never exposed. Further studies are
needed to investigate specifically which chemicals those are carcinogenic.
Cecilia Videnros is doing her PhD at Karolinska Institute
in Stockholm, Sweden, department Institute of Environ-
mental Medicine. Her PhD is within the field Chemicals
and Cancer and she works with big epidemiological data.
cecilia.videnros@ki.seBIOGRAPHY